Genomics and Genetics Weekly

Hepatocellular Carcinoma - Molecular markers evolve early in hepatitis B virus-related liver cancer

Hepatology - The transcription factors Snail and SIP1 heighten liver cancer invasion

Herpesvirus - HHV-8 vFLIP essential for survival of infected lymphoma cells

Hirschsprung Disease - Discovery may help physicians diagnose, treat devastating childhood ailment

Immunology - E2A protein regulates marginal zone B-cell development

Immunology - Neuropeptides do not induce mediator release in isolated intestinal mast cells

Immunology - Novel polymorphism in cytoplasmic region of IgA Fc receptor gene found

Immunology - TOX plays calcineurin-dependent role in CD8 cell lineage commitment

Infectious Disease - Modes of hantavirus transmission inferred from mitochondrial DNA analyses

Kidney Transplantation - Immunosuppressants may hasten oncogenesis in patients with p53 mutations

Lipogenesis - Liver X receptors stimulate adipocyte differentiation via PPAR-gamma

Lipogenesis - Notch target gene plays dual roles in differentiation of preadipocytes

Liver Cancer - Novel PCR-array system useful for gene expression profiling

Lung Cancer - Lung screening test may prove useful as first line of lung cancer testing

Lung Cancer - Variations in DNA repair genes may predict survival in lung cancer patients

Malaria - Proteomics in malaria reviewed

Medical Devices - Immunoassay for detection of irradiated prawns developed

Metabolism - Scientists discover way to regulate the body's energy expenditure

Metapneumovirus - Human metapneumovirus recovered from cDNA

Metastases - Metastatic potential may be a genetic feature of the primary tumor

Molecular Diagnostics - Molecular typing techniques are useful for detecting pathogenic fungi

Mutagenesis - PTEN gene alterations don't appear to impact synovial sarcoma prognosis

Neural Tube Defects - Low erythrocyte folate status, gene polymorphisms increase risk

Neuroblastoma - Salvage therapy influences survival in children with recurrent neuroblastoma

Neurology - Study shows restless legs syndrome under-diagnosed

Neuroscience - Alterations in tau transcripts correlate with sporadic tauopathy neurofilament

Neuroscience - proNGF exhibits neurotrophic activity but is less active than mature NGF

Obesity Therapy - Leptin induces patterns of immediate early gene expression in the brain

Obstetrics - Factor V Leiden associated with increased risk of obstetric complications

Oncogenesis - Many genes synergize with Cbfb-MYH11 to produce acute myeloid leukemia

Oncology - Human prostaglandin F synthase reigns in respiratory and digestive tract tumors

Ovarian Cancer - Anti-tumor responses induced by ovarian cancer protein characterized

Ovarian Cancer - GSTP1 genotypes, expression, and outcome described in ovarian cancer

Ovarian Cancer - Gonadotropin-induced gene regulation may increase cancer risk

Parasitology - Functional genomics for parasitic nematodes and platyhelminths reviewed

Parkinson Disease - Parkinson disease mutations affect axonal transport in cultured neurons

Patents - U.S. patent granted for its Immunogene therapy for cancer

Periodontal Disease - TaqMan PCR assay detects six species of periodontopathic bacteria

Pharmacogenomics - Pharmacogenomics could lower health care costs, investigators report

Phenotyping - EBV-transformed B-cell lines used for reference and research in routine lab

Polymerase Chain Reaction - Short PNA molecular beacons discriminate nucleotide polymorphisms

Preeclampsia - Study finds molecular variant of ACE associated with hypertension in pregnancy

Preimplantation Genetic Diagnosis - Study shows PGD feasible for Sanjad-Sakati syndrome

Prostate Cancer - Array CGH superior to standard CGH for detection of DNA loss

RNA Research - RNA interference-based microarray developed

Recurrent Spontaneous Abortion - Study refutes suggested link between RSA and skewed X chromosome

Respiratory Disease - New studies focus on overproduction of mucus

Ribosome - Decreased repeat lengths encourage transgene stability after transfection

Skin Cancer - More UVA than UVB fingerprint mutations in basal layer of human squamous tumors

Stem-Cell Research - Developing neonatal rabbit appendix is seeded by immature blood-borne B cells

Stem-Cell Research - Louisiana house committee approves ban on reproductive human cloning

Stem-Cell Research - Novel DZIP gene expressed in embryonic stem cells and germ cells is identified

Stem-Cell Research - Nucleosome remodeling defect prevents IL-12(P35) transcription in neonatal DC

Stem-Cell Research - Pluripotent stem cell line expressing the AML1-ETO fusion protein established

Stem-Cell Research - Poly(NiPA-co-AAc) gel may provide optimal chondrocyte propagation 3D environment

Stem-Cell Research - Skeletal muscle differentiation potential of adult BM cells may lead to therapy

Tissue Engineering - Endocytosis of nano-environment produced by colloidal lithography by fibroblasts

Tumor Development - Neuroblastomas exposed to hypoxia undergo genetic shifts

Tumorigenesis - Acquired periostin expression promotes breast cancer angiogenesis

Vaccines - DNA system to support research on vaccine devlivery

Viral Disease - Biotech company testing possible antidote for bioterrorism viruses

Viral Genomics & Genetics - Two subtypes of hepatitis B virus genotype B flourish in Japan

Viral Genomics and Genetics - New hepatitis C virus models will expand research possibilities

Virology - Hepatitis E virus can replicate in primate cells in vitro

Wound Care - Insulin-like growth factor-I alters the effects of thermal trauma in rats