Genomics and Genetics Weekly

Amyotrophic Lateral Sclerosis - Gene research shows Lou Gehrig disease may be treated or prevented

Breast Cancer - Gene polymorphism may be risk factor for increased disease susceptibility

Gene Expression - HIV-1 Tip110 is a negative regulator of AR transcriptional activation

Reproductive Genetics - Researchers identify gene regulating aging and fertility

Wolfram Syndrome - Genetic studies in Spanish Wolfram syndrome families reported

Allergy & Immunology - 4-tert-octylphenol exposure enhances IL-4 production via NF-AT activation

Allergy & Immunology - TNF-alpha and TGF-beta genotypes associated with allergic rhinitis and asthma

Amoebiasis - Polymerase chain reaction repudiates microscopic analyses of enteric amoebas

Angiology - Floating collagen gels support phenotypic variety in large vessel endothelia

Antiphospholipid Syndrome - Anticardiolipin antibodies play a role in thrombosis and stroke

Antiviral Therapy - MxA gene polymorphisms influence interferon efficacy in HCV-positive patients

Arrhythmias - Human genomics may affect the management of patients with arrhythmias

Bacteriology - Novel secreted enzyme from E. faecalis may cause pathogenesis and persistance

Bioinformatics - Gene selection method helps to achieve improved data quality

Bioinformatics - Scientists develop new tool for exploration, integration of biological data

Brain Cancer - Caldesmon gene splice variants are different in the glioma vascular system

Breast Cancer - Interleukin-12 intervenes in the growth of murine mammary tumors

Breast Cancer - Psychosocial telephone counseling not a hit with BRCA mutation carriers

Breast Cancer - sHER-2/neu status predictive indicator for benefit from paclitaxel chemotherapy

Business Update - AstraZeneca selects preferred supplier of siRNA

Cancer Genetics - Communication patterns in families with breast/ovarian cancer history described

Cancer Genomics and Genetics - Genes expressed in head and neck cancer identified

Cancer Progression - Crosstalk between angiogenesis and lymphangiogenesis provokes tumor progression

Cancer Therapy - IND application filed for anticancer compound XL999

Cancer Therapy - Phase I trial of PXD101 begins in patients with hematologic cancer

Candidiasis -  Candida in concentrated oral rinse cultures detected by real-time PCR

Celiac Disease - Pediatric gastroenterologists launch campaign on celiac disease

Cell Biology - The power of angiopoietin ligand systems extends beyond angiogenesis

Cervical Cancer - P73 expression associated with cellular radiosensitivity after radiotherapy

Cervical Cancer - Risk factors compared between U.S. and Venezuela

Chlamydia - Chlamydial histone-DNA interactions are disrupted in isoprenoid biosynthesis

Clinical Genetics - Genetic profiling has advanced our knowledge of non-small cell lung cancer

Collaborations - Applied Biosystems to collaborate on human gene study with Spotfire

Collaborations - Cancer therapeutics alliance formed

Collaborations - Companies team to offer virtual screening protocols for pipelining software

Colorectal Cancer - A new transcriptional regulator derailed in carcinomas

Complementary and Alternative Medicine -  Gardenia jasminoides fruit extract has antiangiogenic properties

Congenital Heart Disease - Understanding left-right organ patterning is a complex process

Cystic Fibrosis - Budget cuts jeopardize medical coverage for individuals with cystic fibrosis

DNA Analysis - New arrays launched for SNP genotyping studies

DNA Synthesis - Pol X family members sponsor DNA repair and recombination

Diabetes Genetics - Diabetes, exocrine pancreatic insufficiency studied in murine model

Diabetes Genetics - Gene polymorphisms and diabetic nephropathy relationship needs investigation

Diabetes Neuropathy - Studies on the genetics of diabetic peripheral neuropathy reviewed

Diabetic Neuropathy - Association of some polymorphic markers with diabetic polyneuropathy studied

Diagnostics - New protein analysis helps scientists identify diseases in humans

Drug Design - Research accelerates discovery of novel gene function

Drug Development - Direct versus indirect genotoxicity classifies pharmaceuticals

Drug Resistance - Paclitaxel resistance in ovarian cancer patients likely multifactorial

Embryonic Development - Telomerase-dependent genetic programs dictate telomere length in embryos

End-Stage Liver Disease - Steatosis accompanies recurrent hepatitis C infection after liver transplants

Endocrinology - Molecular signals kindle the genetic forerunner of aldsterone synthase

Endocrinology - Study identifies genetics of fat metabolism, red wine link

Endometrial Cancer - CYP17 and CYP19 genetic polymorphisms may play role in carcinogenesis

Enzymology - Cloned hepatitis C virus NS5B RNA polymerase displays full functionality

Epidemiology - Hepatitis B virus genotypes command pathogenicity

Evolutionary Biology - Ancient vertebrate has vastly different immune system than humans

Evolutionary Biology - Longevity evolved late for humans

Finance - Biomarker company forecasts second-quarter revenue drop

Gene Expression - Combined approaches capture the nature of human microRNA targets

Gene Expression - TaqMan gene expression assays product line expanded

Gene Expresssion - TCR signaling inhibits apoptosis by repressing SRG3 via Ras activation

Gene Polymorphism - Engrailed 2 gene conversions are not associated with schizophrenia

Gene Profiling - SuperArray launches new line of pathway-specific DNA microarrays

Genetic Risk Factor - c-MPL gene mutations generate familial essential thrombocytosis

Genetics - Harvard patent on genetically altered mouse upheld

Genetics - Mother learns family 'curse' has genetic origin

Genetics - Restaurant offers DNA test, and free meal, for Genghis Khan's descendants

Genome Screening - Company enters algorithm-development collaboration with Dr. Paul McKeigue

Genomics - Gladstone Institute to implement standard RNA amplification and labeling system

Genomics - Institute of Environmental Health Sciences expands liver toxicity collaboration

Genomics - Microarrays with toxicologically relevant genes evaluate chemical toxicity

Genomics & Genetics - Transposomes help generate random insertional mutations in Rickettsia prowazekii

Genomics and Genetics - ChIP microarrays can identify genes silenced in cancer

Genomics and Genetics - DNA microarrays suitable for use with peripheral blood cells

Genomics and Genetics - DNA microarrays useful for identification of T-cell activation-related genes

Genomics and Genetics - Duplicate genes increase expression diversity during development

Genomics and Genetics - Microarray of cDNAs from chicken heart progenitors constructed

Genotyping - University of California, Los Angeles, purchases genotyping BeadLab

Geriatrics - Immune reporters monitor young fruit flies for remaining life span

Glioblastoma - Data published on telomerase inhibitor GRN163 in rodent models of brain tumors

HIV/AIDS - Thymic volume associated independently with CD4 cell repopulation after HAART

HIV/AIDS Diagnostics - ViroSeq HIV-1 Genotyping System has decreased performance with non-B subtypes

HIV/AIDS Research - Actin cytoskeleton disruption complements Nef enhancement of HIV-1 infectivity

HIV/AIDS Research - HIV-1 Gag signal promotes interaction with cellular endocytic machinery

HIV/AIDS Research - Human APOBEC3F is another host factor that blocks HIV-1 replication

HIV/AIDS Research - Novel HIV inhibitors generated through hybridization of known ligands

HIV/AIDS Research - mtDNA involved in the pathogenesis of AZT-associated BM progenitor cell toxicity

HIV/AIDS Risk - Study yields new findings about risk of HIV infection

HIV/AIDS Therapy - New therapeutic options for HIV infection