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Genomics & Genetics Weekly

Susan Hasty, Publisher
Table of Contents . . . July 30th, 2004
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Genomics & Genetics Weekly | Other Publications

Amyotrophic Lateral Sclerosis - Gene research shows Lou Gehrig disease may be treated or prevented

Breast Cancer - Gene polymorphism may be risk factor for increased disease susceptibility

Gene Expression - HIV-1 Tip110 is a negative regulator of AR transcriptional activation

Reproductive Genetics - Researchers identify gene regulating aging and fertility

Wolfram Syndrome - Genetic studies in Spanish Wolfram syndrome families reported

Allergy & Immunology - 4-tert-octylphenol exposure enhances IL-4 production via NF-AT activation

Allergy & Immunology - TNF-alpha and TGF-beta genotypes associated with allergic rhinitis and asthma

Amoebiasis - Polymerase chain reaction repudiates microscopic analyses of enteric amoebas

Angiology - Floating collagen gels support phenotypic variety in large vessel endothelia

Antiphospholipid Syndrome - Anticardiolipin antibodies play a role in thrombosis and stroke

Antiviral Therapy - MxA gene polymorphisms influence interferon efficacy in HCV-positive patients

Arrhythmias - Human genomics may affect the management of patients with arrhythmias

Bacteriology - Novel secreted enzyme from E. faecalis may cause pathogenesis and persistance

Bioinformatics - Gene selection method helps to achieve improved data quality

Bioinformatics - Scientists develop new tool for exploration, integration of biological data

Brain Cancer - Caldesmon gene splice variants are different in the glioma vascular system

Breast Cancer - Interleukin-12 intervenes in the growth of murine mammary tumors

Breast Cancer - Psychosocial telephone counseling not a hit with BRCA mutation carriers

Breast Cancer - sHER-2/neu status predictive indicator for benefit from paclitaxel chemotherapy

Business Update - AstraZeneca selects preferred supplier of siRNA

Cancer Genetics - Communication patterns in families with breast/ovarian cancer history described

Cancer Genomics and Genetics - Genes expressed in head and neck cancer identified

Cancer Progression - Crosstalk between angiogenesis and lymphangiogenesis provokes tumor progression

Cancer Therapy - IND application filed for anticancer compound XL999

Cancer Therapy - Phase I trial of PXD101 begins in patients with hematologic cancer

Candidiasis - Candida in concentrated oral rinse cultures detected by real-time PCR

Celiac Disease - Pediatric gastroenterologists launch campaign on celiac disease

Cell Biology - The power of angiopoietin ligand systems extends beyond angiogenesis

Cervical Cancer - P73 expression associated with cellular radiosensitivity after radiotherapy

Cervical Cancer - Risk factors compared between U.S. and Venezuela

Chlamydia - Chlamydial histone-DNA interactions are disrupted in isoprenoid biosynthesis

Clinical Genetics - Genetic profiling has advanced our knowledge of non-small cell lung cancer

Collaborations - Applied Biosystems to collaborate on human gene study with Spotfire

Collaborations - Cancer therapeutics alliance formed

Collaborations - Companies team to offer virtual screening protocols for pipelining software

Colorectal Cancer - A new transcriptional regulator derailed in carcinomas

Complementary and Alternative Medicine - Gardenia jasminoides fruit extract has antiangiogenic properties

Congenital Heart Disease - Understanding left-right organ patterning is a complex process

Cystic Fibrosis - Budget cuts jeopardize medical coverage for individuals with cystic fibrosis

DNA Analysis - New arrays launched for SNP genotyping studies

DNA Synthesis - Pol X family members sponsor DNA repair and recombination

Diabetes Genetics - Diabetes, exocrine pancreatic insufficiency studied in murine model

Diabetes Genetics - Gene polymorphisms and diabetic nephropathy relationship needs investigation

Diabetes Neuropathy - Studies on the genetics of diabetic peripheral neuropathy reviewed

Diabetic Neuropathy - Association of some polymorphic markers with diabetic polyneuropathy studied

Diagnostics - New protein analysis helps scientists identify diseases in humans

Drug Design - Research accelerates discovery of novel gene function

Drug Development - Direct versus indirect genotoxicity classifies pharmaceuticals

Drug Resistance - Paclitaxel resistance in ovarian cancer patients likely multifactorial

Embryonic Development - Telomerase-dependent genetic programs dictate telomere length in embryos

End-Stage Liver Disease - Steatosis accompanies recurrent hepatitis C infection after liver transplants

Endocrinology - Molecular signals kindle the genetic forerunner of aldsterone synthase

Endocrinology - Study identifies genetics of fat metabolism, red wine link

Endometrial Cancer - CYP17 and CYP19 genetic polymorphisms may play role in carcinogenesis

Enzymology - Cloned hepatitis C virus NS5B RNA polymerase displays full functionality

Epidemiology - Hepatitis B virus genotypes command pathogenicity

Evolutionary Biology - Ancient vertebrate has vastly different immune system than humans

Evolutionary Biology - Longevity evolved late for humans

Finance - Biomarker company forecasts second-quarter revenue drop

Gene Expression - Combined approaches capture the nature of human microRNA targets

Gene Expression - TaqMan gene expression assays product line expanded

Gene Expresssion - TCR signaling inhibits apoptosis by repressing SRG3 via Ras activation

Gene Polymorphism - Engrailed 2 gene conversions are not associated with schizophrenia

Gene Profiling - SuperArray launches new line of pathway-specific DNA microarrays

Genetic Risk Factor - c-MPL gene mutations generate familial essential thrombocytosis

Genetics - Harvard patent on genetically altered mouse upheld

Genetics - Mother learns family 'curse' has genetic origin

Genetics - Restaurant offers DNA test, and free meal, for Genghis Khan's descendants

Genome Screening - Company enters algorithm-development collaboration with Dr. Paul McKeigue

Genomics - Gladstone Institute to implement standard RNA amplification and labeling system

Genomics - Institute of Environmental Health Sciences expands liver toxicity collaboration

Genomics - Microarrays with toxicologically relevant genes evaluate chemical toxicity

Genomics & Genetics - Transposomes help generate random insertional mutations in Rickettsia prowazekii

Genomics and Genetics - ChIP microarrays can identify genes silenced in cancer

Genomics and Genetics - DNA microarrays suitable for use with peripheral blood cells

Genomics and Genetics - DNA microarrays useful for identification of T-cell activation-related genes

Genomics and Genetics - Duplicate genes increase expression diversity during development

Genomics and Genetics - Microarray of cDNAs from chicken heart progenitors constructed

Genotyping - University of California, Los Angeles, purchases genotyping BeadLab

Geriatrics - Immune reporters monitor young fruit flies for remaining life span

Glioblastoma - Data published on telomerase inhibitor GRN163 in rodent models of brain tumors

HIV/AIDS - Thymic volume associated independently with CD4 cell repopulation after HAART

HIV/AIDS Diagnostics - ViroSeq HIV-1 Genotyping System has decreased performance with non-B subtypes

HIV/AIDS Research - Actin cytoskeleton disruption complements Nef enhancement of HIV-1 infectivity

HIV/AIDS Research - HIV-1 Gag signal promotes interaction with cellular endocytic machinery

HIV/AIDS Research - Human APOBEC3F is another host factor that blocks HIV-1 replication

HIV/AIDS Research - Novel HIV inhibitors generated through hybridization of known ligands

HIV/AIDS Research - mtDNA involved in the pathogenesis of AZT-associated BM progenitor cell toxicity

HIV/AIDS Risk - Study yields new findings about risk of HIV infection

HIV/AIDS Therapy - New therapeutic options for HIV infection

HIV/AIDS Therapy - Protamine/AS-ODN nanoparticles may be used to inhibit HIV gene expression

Headache and Migraine - The dopamine D2 receptor gene is not involved in migraine symptomatology

Hematology - Neutrophil PRV-1 expression increases in polycythemia vera patients

Hepatitis C Virus - HCV Core protein potent nucleic acid chaperone similar to retroviral NC proteins

Hepatitis C Virus - HCV NS5B protein polymorphisms reflect viral response to combination therapy

Hepatitis C Virus - IFNAR1-mRNA expression in PBMC associated with IFN-alpha response to hepatitis C

Herpes - Suppression of proinflammatory cytokine expression by HSV type 1

Hypothyroidism - Mutations of the TSH-beta subunit gene are linked to thyroid deficiency

Immunology - IAP expression regulates neutrophil apoptosis

Immunology - IL-10 and TGF-beta differ in regulation of aminopeptidase N/CD13 expression

Immunology - IL-10 ligand/receptor gene family provide lead for biological characterization

Immunology - Interferon gamma is essential for Th1 cell differentiation

Immunology - Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells

Immunology - Self-reactive T cells committed to innate immune cell lineage

Immunology - Subsets of CD25 T cells confer distinct suppressive properties upon CD4 cells

Infectious Disease - HCMV NKCC protein localizes to perinucleus during infection

Laboratory Methods - Access to DNA secrets yields better understanding of genes

Laboratory Methods - Scientists develop a better way to copy DNA

Longevity - Mayo Clinic researchers identify gene regulating aging and fertility

Lung Cancer - New data suggest FUS1 therapy may play role in preventing onset of lung cancer

Medical Devices - Portable genetic assay for pathogen detection and analysis developed

Mergers & Acquisitions - AltaGen Biosciences acquired by biological products company

Metastasis - Hypoxia-inducible factors enhance cancer cell dissemination mechanisms

Microbial Identification - Systematic 16S rRNA gene sequencing isolates rare human pathogens

Mutagenesis - Titin gene mutants generate aberrant circulation and vascular morphogenesis

Nanobacteria - Nanobac reacquires rights to market and sell its nanobiotic regimen

Neuroblastoma - Amplifications in chromosome arm 1p identified

Neurodegeneration - Iris pigment epithelial cells show promise as neurotrophic gene vectors

Neuroscience - Age-related changes in hippocampal gene expression identified

Neuroscience - Neuropeptide Y regulated by c-fos in murine dentate gyrus

Neuroscience - RNA mediates neurodegeneration

Neurotoxin - C. botulinum type B neurotoxin gene expression quantitated with RT-PCR assay

Newborn Screening - Report card finds only 21 states offer core newborn screening tests

Non-Insulin Dependent Diabetes - Genetic variability affected paraoxonase activities in NIDDM patients

Obesity - Leptin and its receptor may promote immune dysfunction related to obesity/NHL

Obesity Pathogenesis - Dopamine-3 receptor gene involved in body fat regulation

Oncogenes - Cancer gene MYC emerging as key research target

Oncology - Proteo-genomics system identifies malignant antibody targets

Ovarian Cancer - Proposed disease model is based on morphological and molecular genetic analysis

Pancreatic Cancer - Ad/TRAIL-F/RGD may be potent therapeutic agent for pancreatic cancer

Pancreatic Cancer - Initial clinical data from GVAX pancreatic cancer vaccine program

Patents - Company announces European patent on human P2Y4 receptor

Patents - Company wins patent for detecting genetic variants utilizing base stacking

Pediatrics - PHOX2B gene mutations are not associated with sudden infant death syndrome

Personnel - Children's health company appoints vice president, sales and marketing

Personnel - Kerry J. Flom, PhD, named VP clinical affairs of genetic assessment company

Personnel - deCODE announces departure of executive vice president

Preeclampsia - Monoamine transporter gene expression compared in placentae

Preimplantation Genetic Diagnosis - Real-time PCR clinically useful for single-cell genotyping in blood diseases

Product Licensing - Spire receives catheter license payment from Bard

Prostate Cancer - Novel candidate oncogene identified

Pulmonary Medicine - Nucleotide insertions reverse the cystic fibrosis phenotype in tissue cultures

Regulatory Issues - FDA lifts clinical hold on ocinaplon, subject to protocol review

Reproductive Biology - Endometrial calbindins, Ca²⁺ regulation critical for embryo implantation

Reproductive Medicine - Human-controlled ovarian hyperstimulation outcome is a polygenic trait

Research - Gene expression in the olfactory mucosa provides opportunity for research

Respiratory Virus - DNA flow-thru chip used for typing and subtyping of influenza viruses

Respiratory Virus - Heteroduplex mobility assay detects genetic variants of RSV subgroup A

Restructuring - Drug-discovery company to focus resources on expanding clinical pipeline

Retrovirology - Progenipoietin-1 increases plasmacytoid/myeloid dendritic cells in SIV-infection

Retrovirus - Crystal structure of monomeric RT from MMLV revealed

Sickle Cell Disease - Collaboration to develop and commercialize sickle cell disease treatment

Stem Cell Research - Calcineurin moves stem cells towards differentiation

Stem Cell Research - Hoxb4 is essential for the normal proliferation of hematopoietic progenitors

Stem Cell Research - Stem cell transplantation reverses canine leukocyte adhesion deficiency

Stem Cell Research - Transplanted adult MSCs differentiate in regionally/temporally specific manner

Stem Cell Transplantation - Deletion of chromosome band 13q14 prognostic factor in multiple myeloma with SCT

Stem Cell Transplantation - Hematopoietic SC dose correlates with speed of immune reconstitution after SCT

Stem-Cell Research - 5azaD and TSA can be used to alter the fate of primitive HSCs/HPCs

Stem-Cell Research - GSM signals affect gene expression levels in tumor suppressor p53-deficient ESC

Stem-Cell Research - Growth factors, signalling pathway promote pancreatic gene expression

Stem-Cell Research - Jak 3 absence affects T-cell development

Stem-Cell Research - L3MBTL implications for pathogenesis of myeloid malignancy 20q deletions

Stem-Cell Research - Mechanisms associated with IL-6-induced up-regulation of Jak3 elucidated

Stem-Cell Research - SCL required for normal function of short-term repopulating hematopoietic SCs

Stem-Cell Research - SSEA-1 epitope expression not essential for embryogenesis

Stem-Cell Research - Type I HBEC immortalization may be early step in breast cancer subset initiation

Stem-Cell Transplantation - EBV viral load monitoring best used to enable prompt treatment of PTLDs

Stem-Cell Transplantation - HSCT survival from unrelated donors decreases with increased class I mismatches

Stem-Cell Transplantation - Proactive hNSCT prevents striatal neuron degeneration in Huntington disease

Technology - Spectral Gnomics introduces chip for comparative genomic hydridization

Toxicology - Gene expression profiles reveal the toxicity endpoints of hepatotoxicants

Tumor Suppression - Loss of LGI1 gene activity encourages glioma invasion

Type 2 Diabetes - Role of calpains in diabetes mellitus reviewed

Type I Diabetes - Natural killer cell receptor expression variation seen in animal model

Viral Infection - Viral meningoencephalitis diagnosis easier with modern laboratory techniques

Viral Persistence - Low levels of hepatitis C persist after spontaneous or drug-induced resolution

Viral Pneumonia - Increased SP-A/defensin mRNA coincides with reduced viral load in pneumonia

Virology - Function of adenovirus protein VII elucidated

Virology - Key features of hepatitis delta virus RNA enable genome replication

Weight Gain - Research collaboration to address weight management

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