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Table of Contents . . . July 30th, 2004
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Genomics & Genetics Weekly | Other Publications
Amyotrophic Lateral Sclerosis - Gene research shows Lou Gehrig disease may be treated or prevented
Breast Cancer - Gene polymorphism may be risk factor for increased disease susceptibility
Gene Expression - HIV-1 Tip110 is a negative regulator of AR transcriptional activation
Reproductive Genetics - Researchers identify gene regulating aging and fertility
Wolfram Syndrome - Genetic studies in Spanish Wolfram syndrome families reported
Allergy & Immunology - 4-tert-octylphenol exposure enhances IL-4 production via NF-AT activation
Allergy & Immunology - TNF-alpha and TGF-beta genotypes associated with allergic rhinitis and asthma
Amoebiasis - Polymerase chain reaction repudiates microscopic analyses of enteric amoebas
Angiology - Floating collagen gels support phenotypic variety in large vessel endothelia
Antiphospholipid Syndrome - Anticardiolipin antibodies play a role in thrombosis and stroke
Antiviral Therapy - MxA gene polymorphisms influence interferon efficacy in HCV-positive patients
Arrhythmias - Human genomics may affect the management of patients with arrhythmias
Bacteriology - Novel secreted enzyme from E. faecalis may cause pathogenesis and persistance
Bioinformatics - Gene selection method helps to achieve improved data quality
Bioinformatics - Scientists develop new tool for exploration, integration of biological data
Brain Cancer - Caldesmon gene splice variants are different in the glioma vascular system
Breast Cancer - Interleukin-12 intervenes in the growth of murine mammary tumors
Breast Cancer - Psychosocial telephone counseling not a hit with BRCA mutation carriers
Breast Cancer - sHER-2/neu status predictive indicator for benefit from paclitaxel chemotherapy
Business Update - AstraZeneca selects preferred supplier of siRNA
Cancer Genetics - Communication patterns in families with breast/ovarian cancer history described
Cancer Genomics and Genetics - Genes expressed in head and neck cancer identified
Cancer Progression - Crosstalk between angiogenesis and lymphangiogenesis provokes tumor progression
Cancer Therapy - IND application filed for anticancer compound XL999
Cancer Therapy - Phase I trial of PXD101 begins in patients with hematologic cancer
Candidiasis - Candida in concentrated oral rinse cultures detected by real-time PCR
Celiac Disease - Pediatric gastroenterologists launch campaign on celiac disease
Cell Biology - The power of angiopoietin ligand systems extends beyond angiogenesis
Cervical Cancer - P73 expression associated with cellular radiosensitivity after radiotherapy
Cervical Cancer - Risk factors compared between U.S. and Venezuela
Chlamydia - Chlamydial histone-DNA interactions are disrupted in isoprenoid biosynthesis
Clinical Genetics - Genetic profiling has advanced our knowledge of non-small cell lung cancer
Collaborations - Applied Biosystems to collaborate on human gene study with Spotfire
Collaborations - Cancer therapeutics alliance formed
Collaborations - Companies team to offer virtual screening protocols for pipelining software
Colorectal Cancer - A new transcriptional regulator derailed in carcinomas
Complementary and Alternative Medicine - Gardenia jasminoides fruit extract has antiangiogenic properties
Congenital Heart Disease - Understanding left-right organ patterning is a complex process
Cystic Fibrosis - Budget cuts jeopardize medical coverage for individuals with cystic fibrosis
DNA Analysis - New arrays launched for SNP genotyping studies
DNA Synthesis - Pol X family members sponsor DNA repair and recombination
Diabetes Genetics - Diabetes, exocrine pancreatic insufficiency studied in murine model
Diabetes Genetics - Gene polymorphisms and diabetic nephropathy relationship needs investigation
Diabetes Neuropathy - Studies on the genetics of diabetic peripheral neuropathy reviewed
Diabetic Neuropathy - Association of some polymorphic markers with diabetic polyneuropathy studied
Diagnostics - New protein analysis helps scientists identify diseases in humans
Drug Design - Research accelerates discovery of novel gene function
Drug Development - Direct versus indirect genotoxicity classifies pharmaceuticals
Drug Resistance - Paclitaxel resistance in ovarian cancer patients likely multifactorial
Embryonic Development - Telomerase-dependent genetic programs dictate telomere length in embryos
End-Stage Liver Disease - Steatosis accompanies recurrent hepatitis C infection after liver transplants
Endocrinology - Molecular signals kindle the genetic forerunner of aldsterone synthase
Endocrinology - Study identifies genetics of fat metabolism, red wine link
Endometrial Cancer - CYP17 and CYP19 genetic polymorphisms may play role in carcinogenesis
Enzymology - Cloned hepatitis C virus NS5B RNA polymerase displays full functionality
Epidemiology - Hepatitis B virus genotypes command pathogenicity
Evolutionary Biology - Ancient vertebrate has vastly different immune system than humans
Evolutionary Biology - Longevity evolved late for humans
Finance - Biomarker company forecasts second-quarter revenue drop
Gene Expression - Combined approaches capture the nature of human microRNA targets
Gene Expression - TaqMan gene expression assays product line expanded
Gene Expresssion - TCR signaling inhibits apoptosis by repressing SRG3 via Ras activation
Gene Polymorphism - Engrailed 2 gene conversions are not associated with schizophrenia
Gene Profiling - SuperArray launches new line of pathway-specific DNA microarrays
Genetic Risk Factor - c-MPL gene mutations generate familial essential thrombocytosis
Genetics - Harvard patent on genetically altered mouse upheld
Genetics - Mother learns family 'curse' has genetic origin
Genetics - Restaurant offers DNA test, and free meal, for Genghis Khan's descendants
Genome Screening - Company enters algorithm-development collaboration with Dr. Paul McKeigue
Genomics - Gladstone Institute to implement standard RNA amplification and labeling system
Genomics - Institute of Environmental Health Sciences expands liver toxicity collaboration
Genomics - Microarrays with toxicologically relevant genes evaluate chemical toxicity
Genomics & Genetics - Transposomes help generate random insertional mutations in Rickettsia prowazekii
Genomics and Genetics - ChIP microarrays can identify genes silenced in cancer
Genomics and Genetics - DNA microarrays suitable for use with peripheral blood cells
Genomics and Genetics - DNA microarrays useful for identification of T-cell activation-related genes
Genomics and Genetics - Duplicate genes increase expression diversity during development
Genomics and Genetics - Microarray of cDNAs from chicken heart progenitors constructed
Genotyping - University of California, Los Angeles, purchases genotyping BeadLab
Geriatrics - Immune reporters monitor young fruit flies for remaining life span
Glioblastoma - Data published on telomerase inhibitor GRN163 in rodent models of brain tumors
HIV/AIDS - Thymic volume associated independently with CD4 cell repopulation after HAART
HIV/AIDS Diagnostics - ViroSeq HIV-1 Genotyping System has decreased performance with non-B subtypes
HIV/AIDS Research - Actin cytoskeleton disruption complements Nef enhancement of HIV-1 infectivity
HIV/AIDS Research - HIV-1 Gag signal promotes interaction with cellular endocytic machinery
HIV/AIDS Research - Human APOBEC3F is another host factor that blocks HIV-1 replication
HIV/AIDS Research - Novel HIV inhibitors generated through hybridization of known ligands
HIV/AIDS Research - mtDNA involved in the pathogenesis of AZT-associated BM progenitor cell toxicity
HIV/AIDS Risk - Study yields new findings about risk of HIV infection
HIV/AIDS Therapy - New therapeutic options for HIV infection
HIV/AIDS Therapy - Protamine/AS-ODN nanoparticles may be used to inhibit HIV gene expression
Headache and Migraine - The dopamine D2 receptor gene is not involved in migraine symptomatology
Hematology - Neutrophil PRV-1 expression increases in polycythemia vera patients
Hepatitis C Virus - HCV Core protein potent nucleic acid chaperone similar to retroviral NC proteins
Hepatitis C Virus - HCV NS5B protein polymorphisms reflect viral response to combination therapy
Hepatitis C Virus - IFNAR1-mRNA expression in PBMC associated with IFN-alpha response to hepatitis C
Herpes - Suppression of proinflammatory cytokine expression by HSV type 1
Hypothyroidism - Mutations of the TSH-beta subunit gene are linked to thyroid deficiency
Immunology - IAP expression regulates neutrophil apoptosis
Immunology - IL-10 and TGF-beta differ in regulation of aminopeptidase N/CD13 expression
Immunology - IL-10 ligand/receptor gene family provide lead for biological characterization
Immunology - Interferon gamma is essential for Th1 cell differentiation
Immunology - Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells
Immunology - Self-reactive T cells committed to innate immune cell lineage
Immunology - Subsets of CD25 T cells confer distinct suppressive properties upon CD4 cells
Infectious Disease - HCMV NKCC protein localizes to perinucleus during infection
Laboratory Methods - Access to DNA secrets yields better understanding of genes
Laboratory Methods - Scientists develop a better way to copy DNA
Longevity - Mayo Clinic researchers identify gene regulating aging and fertility
Lung Cancer - New data suggest FUS1 therapy may play role in preventing onset of lung cancer
Medical Devices - Portable genetic assay for pathogen detection and analysis developed
Mergers & Acquisitions - AltaGen Biosciences acquired by biological products company
Metastasis - Hypoxia-inducible factors enhance cancer cell dissemination mechanisms
Microbial Identification - Systematic 16S rRNA gene sequencing isolates rare human pathogens
Mutagenesis - Titin gene mutants generate aberrant circulation and vascular morphogenesis
Nanobacteria - Nanobac reacquires rights to market and sell its nanobiotic regimen
Neuroblastoma - Amplifications in chromosome arm 1p identified
Neurodegeneration - Iris pigment epithelial cells show promise as neurotrophic gene vectors
Neuroscience - Age-related changes in hippocampal gene expression identified
Neuroscience - Neuropeptide Y regulated by c-fos in murine dentate gyrus
Neuroscience - RNA mediates neurodegeneration
Neurotoxin - C. botulinum type B neurotoxin gene expression quantitated with RT-PCR assay
Newborn Screening - Report card finds only 21 states offer core newborn screening tests
Non-Insulin Dependent Diabetes - Genetic variability affected paraoxonase activities in NIDDM patients
Obesity - Leptin and its receptor may promote immune dysfunction related to obesity/NHL
Obesity Pathogenesis - Dopamine-3 receptor gene involved in body fat regulation
Oncogenes - Cancer gene MYC emerging as key research target
Oncology - Proteo-genomics system identifies malignant antibody targets
Ovarian Cancer - Proposed disease model is based on morphological and molecular genetic analysis
Pancreatic Cancer - Ad/TRAIL-F/RGD may be potent therapeutic agent for pancreatic cancer
Pancreatic Cancer - Initial clinical data from GVAX pancreatic cancer vaccine program
Patents - Company announces European patent on human P2Y4 receptor
Patents - Company wins patent for detecting genetic variants utilizing base stacking
Pediatrics - PHOX2B gene mutations are not associated with sudden infant death syndrome
Personnel - Children's health company appoints vice president, sales and marketing
Personnel - Kerry J. Flom, PhD, named VP clinical affairs of genetic assessment company
Personnel - deCODE announces departure of executive vice president
Preeclampsia - Monoamine transporter gene expression compared in placentae
Preimplantation Genetic Diagnosis - Real-time PCR clinically useful for single-cell genotyping in blood diseases
Product Licensing - Spire receives catheter license payment from Bard
Prostate Cancer - Novel candidate oncogene identified
Pulmonary Medicine - Nucleotide insertions reverse the cystic fibrosis phenotype in tissue cultures
Regulatory Issues - FDA lifts clinical hold on ocinaplon, subject to protocol review
Reproductive Biology - Endometrial calbindins, Ca2+ regulation critical for embryo implantation
Reproductive Medicine - Human-controlled ovarian hyperstimulation outcome is a polygenic trait
Research - Gene expression in the olfactory mucosa provides opportunity for research
Respiratory Virus - DNA flow-thru chip used for typing and subtyping of influenza viruses
Respiratory Virus - Heteroduplex mobility assay detects genetic variants of RSV subgroup A
Restructuring - Drug-discovery company to focus resources on expanding clinical pipeline
Retrovirology - Progenipoietin-1 increases plasmacytoid/myeloid dendritic cells in SIV-infection
Retrovirus - Crystal structure of monomeric RT from MMLV revealed
Sickle Cell Disease - Collaboration to develop and commercialize sickle cell disease treatment
Stem Cell Research - Calcineurin moves stem cells towards differentiation
Stem Cell Research - Hoxb4 is essential for the normal proliferation of hematopoietic progenitors
Stem Cell Research - Stem cell transplantation reverses canine leukocyte adhesion deficiency
Stem Cell Research - Transplanted adult MSCs differentiate in regionally/temporally specific manner
Stem Cell Transplantation - Deletion of chromosome band 13q14 prognostic factor in multiple myeloma with SCT
Stem Cell Transplantation - Hematopoietic SC dose correlates with speed of immune reconstitution after SCT
Stem-Cell Research - 5azaD and TSA can be used to alter the fate of primitive HSCs/HPCs
Stem-Cell Research - GSM signals affect gene expression levels in tumor suppressor p53-deficient ESC
Stem-Cell Research - Growth factors, signalling pathway promote pancreatic gene expression
Stem-Cell Research - Jak 3 absence affects T-cell development
Stem-Cell Research - L3MBTL implications for pathogenesis of myeloid malignancy 20q deletions
Stem-Cell Research - Mechanisms associated with IL-6-induced up-regulation of Jak3 elucidated
Stem-Cell Research - SCL required for normal function of short-term repopulating hematopoietic SCs
Stem-Cell Research - SSEA-1 epitope expression not essential for embryogenesis
Stem-Cell Research - Type I HBEC immortalization may be early step in breast cancer subset initiation
Stem-Cell Transplantation - EBV viral load monitoring best used to enable prompt treatment of PTLDs
Stem-Cell Transplantation - HSCT survival from unrelated donors decreases with increased class I mismatches
Stem-Cell Transplantation - Proactive hNSCT prevents striatal neuron degeneration in Huntington disease
Technology - Spectral Gnomics introduces chip for comparative genomic hydridization
Toxicology - Gene expression profiles reveal the toxicity endpoints of hepatotoxicants
Tumor Suppression - Loss of LGI1 gene activity encourages glioma invasion
Type 2 Diabetes - Role of calpains in diabetes mellitus reviewed
Type I Diabetes - Natural killer cell receptor expression variation seen in animal model
Viral Infection - Viral meningoencephalitis diagnosis easier with modern laboratory techniques
Viral Persistence - Low levels of hepatitis C persist after spontaneous or drug-induced resolution
Viral Pneumonia - Increased SP-A/defensin mRNA coincides with reduced viral load in pneumonia
Virology - Function of adenovirus protein VII elucidated
Virology - Key features of hepatitis delta virus RNA enable genome replication
Weight Gain - Research collaboration to address weight management
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