Genomics & Genetics Weekly
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Antiviral Therapy
MxA gene polymorphisms influence interferon efficacy in HCV-positive patients
July 30th, 2004
MxA gene polymorphisms influence interferon efficacy in HCV-positive patients. "The biological activity of interferon (IFN) is mediated by the induction of intracellular antiviral proteins, such as 2'-5' oligoadenylate synthetase, dsRNA-activated protein kinase and MxA protein. Among these, MxA protein is assumed to be the most specific surrogate parameter for IFN action. This study was performed to elucidate whether a single nucleotide polymorphism (SNP) (G/T at nt-88) in the promoter region of the MxA gene influences the response to IFN therapy in patients with chronic hepatitis C virus (HCV) infection," investigators in Japan report. ...
Source: Genomics & Genetics Weekly (2004-07-30)
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