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Genomics & Genetics Weekly

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Bacteriology



Novel secreted enzyme from E. faecalis may cause pathogenesis and persistance



July 30th, 2004

A novel secreted enzyme from Enterococcus faecalis may be responsible for pathogenesis and persistence of E. faecalis infection.

According to a study from the United States, "The human pathogen Enterococcus faecalis can degrade the N-linked glycans of human RNase B to acquire nutrients, but no gene or protein has been associated with this activity."

"We identified an 88-kDa secreted protein, endoglycosidase (Endo) E, which is most likely responsible for this activity. EndoE, encoded by ndoE, consists of an alpha-domain with a family 18 glycosyl hydrolase motif and a beta-domain similar to family 20 glycosyl hydrolases.

...


Source: Genomics & Genetics Weekly (2004-07-30)

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