Genomics & Genetics Weekly
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Brain Cancer
Caldesmon gene splice variants are different in the glioma vascular system
July 30th, 2004
Caldesmon gene splice variants are different in the glioma vascular system. "Caldesmon is a cytoskeleton-associated protein which has not yet been related to neoplastic angiogenesis. In this study we investigated the expression of the caldesmon gene (CALD1) splicing variants and the protein expression level in glioma microvessels versus normal brain microvasculature," investigators in the Netherlands report. "To exclude sources of splice variant expression from non-vascular components all possible cellular components present in control and glioma samples were pre-screened by laser-capture microdissection followed by reverse transcription-polymerase...
Source: Genomics & Genetics Weekly (2004-07-30)
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