Genomics & Genetics Weekly
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Cancer Progression
Crosstalk between angiogenesis and lymphangiogenesis provokes tumor progression
July 30th, 2004
Crosstalk between angiogenesis and lymphangiogenesis provokes tumor progression. "Extensive studies have identified reliable markers of lymphatic endothelial cells and mechanisms and molecules that regulate development and growth of the lymphatic vessels. Vascular endothelial growth factors (VEGF)-C and VEGF-D, and their cognate receptor tyrosine kinase, VEGF receptor-3 (VEGFR-3), are critical regulators of lymphangiogenesis. By binding to its endothelial cell surface receptors VEGFR-1 and VEGFR-2, VEGF-A mediates vascular leakage, endothelial proliferation and migration," investigators in Italy report. "Angiopoietin-2 (Ang-2) is expressed at sites...
Source: Genomics & Genetics Weekly (2004-07-30)
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