Genomics & Genetics Weekly
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Cell Biology
The power of angiopoietin ligand systems extends beyond angiogenesis
July 30th, 2004
The power of angiopoietin ligand systems extends beyond angiogenesis. According to recent research published in the journal Blood, "the angiopoietins Ang-1 and Ang-2 have been identified as ligands with opposing functions of the receptor tyrosine kinase Tie-2 regulating endothelial cell survival and vascular maturation. Ang-1 acts in a paracrine agonistic manner, whereas Ang-2 appears to act primarily as an autocrine antagonistic regulator." "To shed further light on the complexity of autocrine/paracrine agonistic/antagonistic functions of the angiopoietin/Tie-2 system, we have studied Ang-2 synthesis and secretion in different populations of...
Source: Genomics & Genetics Weekly (2004-07-30)
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