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Breast Cancer
Gene polymorphism may be risk factor for increased disease susceptibility
July 30th, 2004
A polymorphism in the CYP11A gene may be a risk factor for increased susceptibility for breast cancer risk. According to W. Zheng and colleagues, Vanderbilt University, Nashville, Tennessee, "The CYP11A gene encodes the cholesterol side-chain cleavage enzyme (P450scc) that catalyzes the first and rate-limiting step for the biosynthesis of sex hormones. A pentanucleotide repeat [(TAAAA)n] polymorphism in the 5' of the CYP11A gene has been reported to be related to the risk of polycystic ovary syndrome, an inherited endocrine disorder characterized by hyper-androgenemia. "We investigated the association of this polymorphism with breast cancer risk in...
Source: Genomics & Genetics Weekly (2004-07-30)
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