Genomics & Genetics Weekly
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Chlamydia
Chlamydial histone-DNA interactions are disrupted in isoprenoid biosynthesis
July 30th, 2004
Chlamydial histone-DNA interactions are disrupted in isoprenoid biosynthesis. According to researchers in Montana, "The chlamydial developmental cycle is characterized by an intracellular replicative form, termed the reticulate body, and an extracellular form called the elementary body. Elementary bodies are characterized by a condensed chromatin, which is maintained by a histone H1-like protein, Hc1. "Differentiation of elementary bodies to reticulate bodies is accompanied by dispersal of the chromatin as chlamydiae become transcriptionally active, although the mechanisms of Hc1 release from DNA have remained unknown," explained N.A. Grieshaber and...
Source: Genomics & Genetics Weekly (2004-07-30)
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