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Congenital Heart Disease
Understanding left-right organ patterning is a complex process
July 30th, 2004
Researchers must understand molecular biology, embryology, pediatrics, and internal medicine to understand left-right patterning malformations. According to recent research from Australia, "It is increasingly recognized that mutations in genes and pathways critical for left-right (L-R) patterning are involved in common isolated congenital malformations, such as congenital heart disease, biliary tract anomalies, renal polycystic disease, and malrotation of the intestine, indicating that disorders of L-R development are far more common than a 1 in 10,000 incidence of heterotaxia might suggest." "Understanding L-R patterning disorders requires knowledge...
Source: Genomics & Genetics Weekly (2004-07-30)
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