Genomics & Genetics Weekly
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Gene Expression
HIV-1 Tip110 is a negative regulator of AR transcriptional activation
July 30th, 2004
HIV-1 Tip110 is a negative regulator of androgen receptor transcriptional activation. According to recent research from the United States, "Upon binding to androgen, androgen receptor (AR) can activate expression of target genes through its direct binding to the androgen- responsive elements (AREs), which are located within the target gene promoters and/ or enhancers." "A number of cellular proteins have been identified as co- regulators to regulate this transactivation process. One common structural feature among these co- regulators is the presence of the LXXLL motif (X, any amino acid)," said Y. Liu and colleagues, "the so- called nuclear receptor...
Source: Genomics & Genetics Weekly (2004-07-30)
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