Genomics & Genetics Weekly
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Diabetes Genetics
Diabetes, exocrine pancreatic insufficiency studied in murine model
July 30th, 2004
Diabetes and exocrine pancreatic insufficiency has been studied in a mutant mouse model. Researchers writing in the Journal of Clinical Investigation said, "E2F transcription factors are thought to be key regulators of cell growth control. Here we use mutant mouse strains to investigate the function of E2F1 and E2F2 in vivo. E2F1/E2F2 compound-mutant mice develop non-autoimmune insulin-deficient diabetes and exocrine pancreatic dysfunction characterized by endocrine and exocrine cell dysplasia, a reduction in the number and size of acini and islets, and their replacement by ductal structures and adipose tissue." A. Iglesias and colleagues,...
Source: Genomics & Genetics Weekly (2004-07-30)
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