Genomics & Genetics Weekly
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Drug Development
Direct versus indirect genotoxicity classifies pharmaceuticals
July 30th, 2004
Direct versus indirect genotoxicity classifies pharmaceuticals. According to published research from the United States, "during the safety evaluation process of new drugs and chemicals, a battery of genotoxicity tests is conducted starting with in vitro genotoxicity assays. Obtaining positive results in in vitro genotoxicity tests is not uncommon. Follow-up studies to determine the biological relevance of positive genotoxicity results are costly, time consuming, and utilize animals." "More efficient methods, especially for identifying a putative mode of action like an indirect mechanism of genotoxicity (where DNA molecules are not the initial primary...
Source: Genomics & Genetics Weekly (2004-07-30)
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