Genomics & Genetics Weekly
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Embryonic Development
Telomerase-dependent genetic programs dictate telomere length in embryos
July 30th, 2004
Telomerase-dependent genetic programs dictate telomere length in embryos. According to a study from Germany, "the enzyme telomerase is active in germ cells and early embryonic development and is crucial for the maintenance of telomere length. Whereas the different length of telomeres in germ cells and somatic cells is well documented, information on telomere length regulation during embryogenesis is lacking. In this study, we demonstrate a telomere elongation program at the transition from morula to blastocyst in mice and cattle that establishes a specific telomere length set point during embryogenesis." "We show that this process restores telomeres...
Source: Genomics & Genetics Weekly (2004-07-30)
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