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Endometrial Cancer
CYP17 and CYP19 genetic polymorphisms may play role in carcinogenesis
July 30th, 2004
Polymorphisms of CYP17 and CYP19 genes may be involved in development of endometrial cancer, according to a report from Russia. "Excessive estrogenic influence is known to be associated with initiation/promotion of endometrial cancer (EC). Allelic polymorphisms of the genes involved in steroidogenesis/steroid metabolism may contribute to EC susceptibility. It is important to know endocrine mechanisms by which such susceptibility is acquired," wrote L.M. Berstein and colleagues at the N.N. Petrov Oncology Research Institute in St. Petersburg. The researchers "compared CYP19 (aromatase) and CYP17 (17alpha-hydroxylase/17,20-lyase) gene polymorphisms...
Source: Genomics & Genetics Weekly (2004-07-30)
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