Genomics & Genetics Weekly
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Gene Expression
Combined approaches capture the nature of human microRNA targets
July 30th, 2004
Combined approaches capture the nature of human microRNA targets. According to published research from the United States, "a new paradigm of gene expression regulation has emerged recently with the discovery of microRNAs (miRNAs). Most, if not all, miRNAs are thought to control gene expression, mostly by base pairing with miRNA-recognition elements (MREs) found in their messenger RNA (mRNA) targets. Although a large number of human miRNAs have been reported, many of their mRNA targets remain unknown." "Here we used a combined bioinformatics and experimental approach to identify important rules governing miRNA-MRE recognition that allow prediction of...
Source: Genomics & Genetics Weekly (2004-07-30)
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