Genomics & Genetics Weekly
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Gene Polymorphism
Engrailed 2 gene conversions are not associated with schizophrenia
July 30th, 2004
Engrailed 2 gene conversions are not associated with schizophrenia. "Epidemiological data and family studies in schizophrenia show that genetic factors contribute to the vulnerability to this disorder. The homeogene Engrailed 2 (EN2) is specifically involved in patterning the region that gives rise to the cerebellum and controls the plasticity of midbrain dopaminergic neurons," scientists in France report. "We carried out an association study for a CA repeat polymorphism located in the 3' region of the homeogene EN2," wrote D. Gourion and colleagues, INSERM E117. "The subjects consisted of 165 patients with schizophrenia and 97...
Source: Genomics & Genetics Weekly (2004-07-30)
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