Genomics & Genetics Weekly
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Allergy & Immunology
4-tert-octylphenol exposure enhances IL-4 production via NF-AT activation
July 30th, 2004
4-tert-octylphenol exposure enhances IL-4 production in T cells via NF-AT activation. "4-tert-Octylphenol (OP) is a representative endocrine disruptor that may have adverse effects on human health. The influence of this compound on allergic immune responses remains unclear. In this study, we have examined the effects of OP on production of interleukin-4 (1L-4), a pro-inflammatory cytokine closely associated with allergic immune responses," scientists in South Korea report. "OP significantly enhanced IL-4 production in antigen-primed T cells in a dose-dependent manner. Treatment with OP in vivo resulted in significant increase of IL-4 production in T...
Source: Genomics & Genetics Weekly (2004-07-30)
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