Genomics & Genetics Weekly
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Angiology
Floating collagen gels support phenotypic variety in large vessel endothelia
July 30th, 2004
Floating collagen gels support phenotypic variety in large vessel endothelia. "The vascular endothelium in vivo is a remarkably quiescent cell layer that displays a highly differentiated and tissue-specific phenotype. Once established in culture, endothelial cells (EC) are phenotypically different from their in situ counterparts, displaying altered gene expression, increased mitotic index, and decreased cell density," scientists in the United States report. "To determine whether manipulating the microenvironment of cells in vitro would lead to a more differentiated phenotype, we cultured bovine aortic EC on floating collagen gels," explained L.H....
Source: Genomics & Genetics Weekly (2004-07-30)
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