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Genomics & Genetics Weekly

Susan Hasty, Publisher
Table of Contents . . . August 6th, 2004
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Genomics & Genetics Weekly | Other Publications

Aging - Researchers discover gene responsible for onset of infertility, cataracts

Bone Regeneration - PRDC is a potent BMP antagonist with a wide tissue expression pattern

Depression - ACE polymorphism affects therapeutic outcome in depressed women

Developmental Biology - Scientists discover key step in the development of nerve cells

Skin Cancer - CDKN2A/ARF gene mutation insignificant risk of FMM or MM in cancer aggregates

Acute Lymphoblastic Leukemia - Novel FLT3 inhibitors may be considered to treat hyperdiploid or relapsed ALL

Acute Myeloid Leukemia - FLT3 mutations in AML adversely associate with CR with intensive chemotherapy

Alcoholism - Microarray analysis identifies changes in liver gene expression

Alzheimer Disease - Effect of citalopram on lymphocyte gene expression characterized

Amyotrophic Lateral Sclerosis - Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor

Antipsychotic Therapy - Antipsychotics upregulate bcl-2 mRNA/protein in frontal cortex and hippocampus

Anxiety Disorder - Serotonin transporter gene variation correlates with social phobia severity

Apoptosis - P300 regulates p53-dependent apoptosis in colorectal cancer cells

Asthma - European approval sought for Xolair as treatment for severe allergic asthma

Asthma - Report: Singapore researchers develop gene-based asthma vaccine

Bacteriology - CGH microarrays useful for analysis of E. coli genome

Biochemistry - Non-electrophoretic assays screen for chemical inhibitors of DNA ligase

Biotechnology - Biosensors identify DNA binding at the single molecular level

Bloom Syndrome - BLM and CAF-1 coordinate to promote survival in response to DNA damage

Breast Cancer - ER codon 594/HER2 codon 655 polymorphisms not associated with breast cancer risk

Breast Cancer - Effect of high-n-6 fat diet on gene expression determined

Breast Cancer - Endocrinological underpinnings elucidated

Breast Cancer - Increased serum folate levels associated with reduced breast cancer risk

Breast Cancer - Tamoxifen metabolite R-isomer forms more DNA adducts in liver cells

Cancer Diagnostics - Oncological impact of gene expression profiling reviewed

Cancer Markers - Molecular markers useful to detect various stages of non-small-cell lung cancer

Carcinogens - Mechanism of benzene-induced leukemia elucidated

Carcinogens - Plutonium cancer risk questioned

Carcinogens - VEGF is a mediator of PCB 104-induced breast cancer cell invasion

Cardiac Development - Disturbed lymphangiogenesis underlies fetal heart malformation

Cardiology - Gene therapy shows promise for treating cardiovascular disease

Cardiomyopathy - Lamin A/C mutations can cause serious heart problems

Cell Biology - Store-operated calcium ion entry regulates vascular smooth muscle gene activity

Cell Regulation - Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation

Cervical Cancer - Nucleotide sequencing-based genotyping used to assess HPV disease link in Japan

Chemotherapy - siRNA against NF-kappaB p65 subunit enhances sensitivity to chemotherapeutics

Chronic Lymphocytic Leukemia - Alemtuzumab effective therapy for CLL with p53 mutations and deletions

Collaborations - Agreement signed with Artemis Pharmaceuticals for transgenic mice

Collaborations - Genomics application licensed from Stanford University

Computer Modeling - SimPheny software licensed to The Wageningen Centre for Food Sciences

DNA Repair - 53BP1 required for class switch recombination

DNA Research - Balanced-PCR facilitates genomic DNA analysis

DNA Research - Microfluidic device suitable for rapid DNA mapping

DNA Research - Mismatch DNA repair heterodimer hMSH2/6 regulates BLM helicase

DNA Research - Single-particle tracking suitable for DNA tether length studies

DNA Research - Versatile microfluidic DNA sequencer developed

Data Mining - Discordant data from microarray platforms make drug research challenging

Depression - Zinc stimulates cortical brain-derived neurotrophic factor gene expression

Dermatology - Genetic studies of psoriasis susceptibility should focus on the PSORS1 locus

Developmental Biology - Cell death protein has surprising role in cell migration

Diagnostics - Label-free gene sensors accelerate studies of nucleic acid binding events

Diagnostics - Methylated DNA collected by tampons detects endometrial cancer

Distribution Agreement - Cepheid expands distribution in China

Dog Genome - Canine genome available now to research community worldwide

Down Syndrome - Markers distinguishing TMD and AMKL identified

Drug Development - CombiMatrix announces human drug metabolism array

Drug Development - Critical human skeletal muscle ischemia displays distinct gene patterning

Drug Development - Gene-based products company expands AAV patent portfolio

Drug Development - Pharmaceuticals company names protein structure service provider

Drug Discovery - De Novo and partner announce successful completion of GPCR Library

Embryogenesis - Delta-like 1 necessary to generate marginal zone B cells, not T cells in vivo

Endocrinology - 3D visualisation model developed for dynamic signaling networks

Endocrinology - Hormone replacement therapy may protect against colon cancer

Endocrinology - Insulin-like growth factor binding protein-3 mediates programmed cell death

Endocrinology - RNA interference might treat growth hormone-related disorders

Epidemiology - Genetic markers identify populations in India

Epilepsy - Several genes associate with the risk for human idiopathic epilepsy

Epstein Barr Virus - EBV viral load increases and reaches setpoint after HIV seroconversion

Finance - Disease-management company applies for listing on American Stock Exchange

Finance - Gene-transfer therapy company announces $9.85 million private placement

Finance - Illumina reports 140% revenue increase over second quarter 2003

Food Safety - Brazil approves BAX system as official method to detect Salmonella

Fungal Infection - Similar P. jirovecii genotypes found in different forms of infection

Gastric Cancer - Runx3 major growth regulator of gastric epithelial cells

Gene Array - CombiMatrix inks comarketing agreement

Gene Detection - An improved microarray-based assay identifies MEFV mutations

Gene Expression - Promoter element location directs testis-specific Hst70/Hsp70.2 expression

Gene Expression - Role of TEL-AML1 fusion gene in molecular pathogenesis of ALL elucidated

Gene Probes - Four-color multiplex assays detect single nucleotide polymorphisms

Gene Reporters - New research determines the kinetics and stability of luciferase

Gene Transfer - Gene transfection can alter social behavior in mammals

Genetics - Gene research group provides ryegrass sequence data to public genomics effort

Genome Analysis - Structure and function of chromosome 13q14 characterized

Genomics - Chiron acquires San Diego company

Genomics - InforSense announces agreement with children's hospital in Canada

Genomics - MAGE-A1-expressing tumor cell 5' region less methylated than other parts of gene

Genomics and Genetics - "Metagene" analysis can improve predictions of disease outcome

Genomics and Genetics - Automated method devised for large-scale cell phenotype screening

Genomics and Genetics - Coexpression analysis of accumulated microarray data reported

Genomics and Genetics - Ensemble decision approach improves identification of disease-linked genes

Genomics and Genetics - Manufacturing data, software system may improve microarray analysis

Genomics and Genetics - Novel gene profiling approach reveals effects of cerebral ischemia

Genomics and Genetics - RAD51D recombination/repair protein required for telomere maintenance

Genomics and Genetics - Ribosome biogenesis factors regulated at post-transcriptional level

Glycogen Storage Disease - TGF-beta upregulation linked to renal interstitial fibrosis in GSD-I

HIV/AIDS - Continued injection drug use not associated with progression to AIDS in women

HIV/AIDS Research - Chromatin structure affects HIV-1/ASV integration site selection opposite ways

HIV/AIDS Research - Differentially expressed genes in HIV-1-resistant cells analyzed by microarray

HIV/AIDS Research - Diketo acid integrase inhibitor resistance impairs HIV-1 replication/integration

HIV/AIDS Research - Resistance mutations sustain or enhance CTL recognition of HIV-1 Pol epitopes

HIV/AIDS Research - Tsg-101 protein has role in HIV Gag particle release

HIV/AIDS Therapy - $14.2 million NIH contract awarded for pathogen drug and diagnostic development

HIV/AIDS Therapy - NNRTI stereochemistry and regiochemistry profoundly affect anti-HIV activity

HIV/AIDS-Related Disease - BCL-6 mutations seen in HIV-related pulmonary lymphoproliferative disorders

Head and Neck Cancer - Protein collusion foretells poor prognoses for maxillary sinus cancer patients

Headache and Migraine - Novel A1A2 Na+/K+-ATPase variants associate with neuropathic disease

Hearing Loss - Profoundly deaf children display GJB6 gene deletions

Hematologic Disease - Hepatitis C virus associates with thrombocytopenia formation

Hematologic Malignancy - Notch-1 signaling mediates BMS influence on hematologic malignant cell growth

Hepatitis C Virus - CHMP recommends approval of shorter course of PegIntron/Rebetol therapy

Hepatocellular Carcinoma - Kinectin splicing in HCC characterized

Hepatocellular Carcinoma - PIN1 overexpression/beta-catenin gene mutations distinct oncogenic events in HCC

Hypercholesterolemia - HMG-CoA reductase inhibitors reduced total cholesterol levels

Hypertension Risk Factor - Proteins associated with bone morphogenetic protein receptor identified

Immunology - Hsp60 and -70 do not activate macrophage cytokine genes

Immunology - Immunoglobulin GM genotype heightens susceptibility to hepatitis C infection

Ischemic Heart Disease - AA variant of the HMOX1 gene reduces ischemic heart disease in Japanese subjects

Leishmaniasis - Developmental genomic changes identified in L. major

Leukemia - Gene profiles could improve acute leukemia diagnosis

Leukemogenesis - Mechanism of leukemogenesis described

Leukemogenesis - Molecular mechanisms of leukemogenesis by AML1/EVI-1 described

Lung Cancer - Upregulated genes identified in ACTH-producing SCLC tumors

Lung Cancer Risk Factor - Coal burning and genetics linked to lung cancer in Xuan Wei, China

Mental Health - Polymorphisms in GABA_A receptor genes correlate with schizophrenia

Mergers & Acquisitions - Peoples Genetics' technologies acquired for genetic analyses

Mergers and Acquisitions - Complete acquisition of Axon Instruments announced

Molecular Diagnostics - MGB Eclipse Detection Reagents launched

Mouse Genome - MICER allows targeted modification of the mouse genome

Muir-Torre Syndrome - Dermatopathologists play role in diagnosis of Muir-Torre syndrome

Mutagenesis - Aprataxin mutations cause early onset ataxia

Neurodegeneration - Sequencing tests suggest human enteroviruses cause motor neuron diseases

Neurodegenerative Disorders - Alpha syrtuclein linked to Parkinson, Alzheimer disease

Neuroscience - Astrocyte diversity characterized at molecular level

Neuroscience - BAI1-AP4 promoter drives transgene expression in murine brains

Neuroscience - Central serotonergic neurons require Ascl1/Mash1 for proper development

Neuroscience - In vivo and in vitro astrocyte gene expression compared

Nucleotide Labeling - Metal-enhanced fluorescence improves the utility of fluorophores

Obesity Genomics & Genetics - Detailed genetic mapping reveals complexity of obesity trait locus

Ocular Diseases - Study: Squalamine effective for extraretinal neovascularization

Oncogene - p21-dependent cell cycle arrest guards against unrestricted cell proliferation

Oncogenes - P13K signaling essential for ABL oncogene-mediated B cell transformation

Oncogenesis - Werner syndrome protein protects the genome from carcinogenic events

Oncology - Hypoxia-inducible factors regulate prolyl hydroxylases

Ophthalmology - Genome scans detect loci common to early-onset primary open-angle glaucoma

Osteoporosis - IL-6-174G/C genotype associated with BMD response to postmenopausal ERT

Pain Medicine - Role of neuropeptide FF in pain modulation elucidated

Peptide Synthesis - Nucleobase switching runs the recognition behavior of peptide ribonucleic acid

Periodontitis - Company reports positive results from Periostat + Atridox study

Personnel - Biopharmaceutical company announces new president and CEO

Personnel - Biotech company names Franklin Berger to board of directors

Personnel - David Ferrick named VP of California biotech/device company

Personnel - Proteomics company names Dr. Wenpei Su as director of genomics applications

Pharmacogenetics - Pharmacogenetics can improve identification of high-risk ALL patients

Pharmacogenomics - Wyeth inks contract for regulatory-compliant pharmacogenomic testing services

Prenatal Genetic Testing - Multiple endocrine neoplasia 2A complications rare with early diagnosis

Privacy - Confidentiality of genetic databases questioned by researchers

Prostate Cancer - New evidence shows Her-2/neu receptor correlates with prostate cancer risk

Psoriasis - Skin condition linked to genetics in Caucasian and Chinese populations

Psychiatry - Neuregulin gene mutations increase one's risk for schizophrenia

Psychology - DUP25 expression doesn't associate with panic disorder

Pulmonary Medicine - Multiplex PCR dissects the etiology of community-acquired pneumonia

RNA Research - Novel EST assembler efficient and versatile

Recombinant Research - Antisense transcription of antigen receptor genes involves V region remodeling

Retinitis Pigmentosa - Vitamins, cell transplants, and other drugs target hereditary eye disease

Retrovirus - HTLV-I dimerization initiation site forms hairpin loop

Rhabdomyosarcoma - Novel t(2;20)(Q35;p12) seen in childhood RMS with embryonal histology

Scleroderma - TGF-beta₁ polymorphisms are not a factor in systemic sclerosis

Stem Cell Research - Apoptosis has role in development of AGM HSC revealed by Bcl-2 overexpression

Stem Cell Research - ESC-derived CD34+CD38-precursors exhibit embryonic gene expression pattern

Stem Cell Research - Reductions in linker histone levels are tolerated in developing spermatocytes

Stem Cell Research - U.S. NIH to open stem-cell bank with tight restrictions

Stem Cell Transplantation - GVHD major predictive factor for response to donor lymphocyte infusions in MM

Stem Cell Transplantation - IL-10/TNF alpha region haplotypes predict mortality after unrelated donor SCT

Tumor Suppression - RUNX3 is a bona fide tumor suppressor of gastric cancers

Tumor Suppression - p300 and CBP are suppressors of hematological tumor formation

Tumor Suppressor Gene - Somatic inactivation of Nfl induces a progressive myeloproliferative disorder

Tumorigenesis - Brca1 and Chk2 have collaborative roles in tumorigenesis

Type 1 Diabetes - Genetic mutation is major contributor to autoimmune diabetes

Viral Genomics - Human adenovirus genomes display resistance to chemical disinfectants

Virology - Spontaneous clearance is common with hepatitis C virus genotype 3 infections

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