Genomics & Genetics Weekly
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Amyotrophic Lateral Sclerosis
Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor
August 6th, 2004
Researchers have found that a large protein, alsin, is a Rab5 and Rac1 guanine nucleotide exchange factor, and may play a role in a juvenile form of amyotrophic lateral sclerosis. "ALS2 is the gene mutated in a recessive juvenile form of amyotrophic lateral sclerosis (ALS2). ALS2 encodes a large protein termed alsin, which contains a number of predicted cell signaling and protein trafficking sequence motifs," scientists in the United States report. "To gain insight into the overall function of alsin and to begin to evaluate its role in motor neuron maintenance, we examined the subcellular localization of alsin and the biochemical activities...
Source: Genomics & Genetics Weekly (2004-08-06)
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