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Antipsychotic Therapy
Antipsychotics upregulate bcl-2 mRNA/protein in frontal cortex and hippocampus
August 6th, 2004
Antipsychotics upregulate bcl-2 mRNA and protein in the frontal cortex and hippocampus. "To investigate whether atypical antipsychotic drugs exert an effect on the neuroprotective protein Bcl-2, rats were chronically treated with clozapine or olanzapine for 28 days. "The expression of bcl-2 mRNA and Bcl-2 protein was determined, respectively, by in situ hybridization in tissue sections and Western blot on tissue samples from rat frontal cortex and hippocampus," researchers in Canada report. "The bcl-2 mRNA positive cells were increased in these regions after drug treatments," said O. Bai and colleagues, "and quantitative analysis...
Source: Genomics & Genetics Weekly (2004-08-06)
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