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Bacteriology
CGH microarrays useful for analysis of E. coli genome
August 6th, 2004
Comparative genomic hybridization (CGH) microarrays are valuable tools for genomic and phylogenic E. coli analysis. "Escherichia coli, including the closely related genus Shigella, is a highly diverse species in terms of genome structure," bacteriologists in Japan noted. In a study conducted by S. Fukiya and colleagues at Kyowa Hakko Kogyo Co. Ltd., CGH microarray analysis was "used to compare the gene content of E. coli K-12 with the gene contents of pathogenic strains." "Missing genes in a pathogen were detected on a microarray slide spotted with 4,071 open reading frames (ORFs) of W3110, a commonly...
Source: Genomics & Genetics Weekly (2004-08-06)
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