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Bloom Syndrome
BLM and CAF-1 coordinate to promote survival in response to DNA damage
August 6th, 2004
BLM and CAF-1 coordinate to promote survival in response to DNA damage. According to recent research published in the journal Molecular and Cellular Biology, "Bloom's syndrome (BS) is a genomic instability disorder characterized by cancer susceptibility. The protein defective in BS, BLM, belongs to the RecQ family of DNA helicases. "In this study, we found that BLM interacts with hp150, the largest subunit of chromatin assembly factor 1 (CAF-1), in vitro and in vivo." "Colocalization of a proportion of the cellular complement of these two proteins is found at specific nuclear foci coinciding with sites of DNA synthesis in...
Source: Genomics & Genetics Weekly (2004-08-06)
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