Genomics & Genetics Weekly
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Breast Cancer
Effect of high-n-6 fat diet on gene expression determined
August 6th, 2004
Genes differentially expressed during a carcinogenic high-n-6 fat diet have been identified using microarray analysis. "In previous studies," oncologists in Spain "demonstrated that high corn oil diets promote the development of 7,12-dimethylbenz(alpha)anthracene (DMBA)-induced mammary tumors." In their subsequent study, E. Escrich and coauthors at the Autonomous University of Barcelona "investigated whether modulation of gene expression is one of the mechanisms by which this high-fat diet exerts such effects." "Female Sprague-Dawley rats were induced with DMBA and fed normolipidic (3% corn oil) or high-fat (20% corn oil) diet,"...
Source: Genomics & Genetics Weekly (2004-08-06)
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