Genomics & Genetics Weekly
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Breast Cancer
Endocrinological underpinnings elucidated
August 6th, 2004
The endocrinological factors underlying breast cancer have been elucidated. "In breast tumors and breast cancer cell (BCC) lines, microarray analyses have revealed that a series of genes are expressed in close association with the estrogen receptor-alpha (ER-alpha) gene, ESR1," scientists in Belgium explained. "Three of them, GATA3, HNF3A (also known as FOXA1), and XBP1 encode transcription factors" with "potential involvement in the ER-alpha-mediated actions in BCC," reported M. Lacroix and colleagues at the Free University of Brussels. Experimental results revealed "relations that exist, or...
Source: Genomics & Genetics Weekly (2004-08-06)
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