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Breast Cancer
Tamoxifen metabolite R-isomer forms more DNA adducts in liver cells
August 6th, 2004
A tamoxifen metabolite R-isomer forms more DNA adducts in liver cells. "The antiestrogenic drug tamoxifen forms DNA adducts in rat liver through two genotoxic metabolites, a-hydroxytamoxifen and alpha-hydroxy-N-desmethyltamoxifen. These have now each been resolved into R- and S-enantiomers. "The work with a-hydroxytamoxifen was published earlier [Osborne, et al, (2001) Chem. Res. Toxicol. 14, 888-893]. Here, we publish results with a-hydroxy-N-desmethyltamoxifen," wrote scientists in the journal Chemical Research in Toxicology. "We prepared the derivative N-ethoxycarbonyl-N-desmethyltamoxifen-alpha-S-camphanate, separated...
Source: Genomics & Genetics Weekly (2004-08-06)
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