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Carcinogens
Mechanism of benzene-induced leukemia elucidated
August 6th, 2004
The mechanism of benzene-induced leukemia has been elucidated. According to published research from the United States, "Acute myeloid leukemia and chronic lymphocytic leukemia are associated with benzene exposure. In mice, benzene induces chromosomal breaks as a primary mode of genotoxicity in the bone marrow (BM). Benzene-induced DNA lesions can lead to changes in hematopoietic stem cells (HSC) that give rise to leukemic clones." "To gain insight into the mechanism of benzene-induced leukemia," B. Faiola and coworkers said, "we investigated the DNA damage repair and response pathways in total bone marrow and bone marrow fractions enriched for HSC...
Source: Genomics & Genetics Weekly (2004-08-06)
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