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Carcinogens
VEGF is a mediator of PCB 104-induced breast cancer cell invasion
August 6th, 2004
VEGF is a mediator of PCB 104-induced breast cancer cell invasion. According to published research from the United States, "polychlorinated biphenyl (PCB) congeners, a group of worldwide, persistent environmental contaminants, are known to cause carcinogenesis and tumor promotion, and may also affect the development of cancer metastasis. Because vascular endothelial cells create a selective barrier to the passage of cancer cells, we hypothesize that specific PCB congeners can disrupt endothelial integrity and increase the transendothelial migration of tumor cells. "To examine this hypothesis, we elucidated the effects of...
Source: Genomics & Genetics Weekly (2004-08-06)
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