Genomics & Genetics Weekly
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Bone Regeneration
PRDC is a potent BMP antagonist with a wide tissue expression pattern
August 6th, 2004
Protein related to DAN and cerberus (PRDC) is a potent bone morphogenetic protein antagonist with a wide tissue expression pattern. "Bone morphogenetic proteins (BMPs) are important for body patterning and morphogenesis, whereas several BMP antagonists regulate the functions of BMPs during embryonic development and tissue differentiation. "Protein related to DAN and cerberus (PRDC) is a secreted protein with a cystine knot structure identified by gene trapping in embryonic stem cells. Although PRDC shows sequence homology with proteins of the BMP antagonist family, its biological activity and physiological functions are unclear," scientists writing...
Source: Genomics & Genetics Weekly (2004-08-06)
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