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Genomics & Genetics Weekly

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Cardiac Development



Disturbed lymphangiogenesis underlies fetal heart malformation



August 6th, 2004

Disturbed lymphangiogenesis underlies fetal heart malformation.

According to recent research published in the journal Developmental Dynamics, "ultrasound measurement of increased nuchal translucency is a method of risk assessment for heart malformations and trisomy 21 in human pregnancy. The developmental background of this nuchal edema is still not sufficiently understood. We have studied the process in trisomy 16 mice that show nuchal edema and heart malformations."

"We used trisomy 16 and wild-type (WT) embryos from embryonic day (E) 12.5 to E18.5. In WT embryos at E13, bilateral jugular lymphatic sacs are visible that share a...


Source: Genomics & Genetics Weekly (2004-08-06)

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