Genomics & Genetics Weekly
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Cell Biology
Store-operated calcium ion entry regulates vascular smooth muscle gene activity
August 6th, 2004
Store-operated calcium ion entry regulates vascular smooth muscle gene activity. "Ca2+-regulated gene transcription is a critical component of arterial responses to injury, hypertension, and tumor-stimulated angiogenesis. The Ca2+/cAMP response element binding protein (CREB), a transcription factor that regulates expression of many genes, is activated by Ca2+-induced phosphorylation. Multiple Ca2+ entry pathways may contribute to CREB activation in vascular smooth muscle including voltage-dependent Ca2+ channels and store-operated Ca2+ entry (SOCE)," scientists in the United States report. "To investigate a role for SOCE in CREB activation, we...
Source: Genomics & Genetics Weekly (2004-08-06)
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