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Cell Regulation
Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation
August 6th, 2004
Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation. According to published research from Japan, "Bcr-Abl tyrosine kinase inhibitor induces apoptosis and erythroid differentiation of K562 cells. During this erythroid differentiation, c-Myc and cyclin D1 transcripts are transiently downregulated. Accordingly, we studied the effect of cyclin D1 overexpression on erythroid differentiation." "After treatment with 250 nM STI571," T. Kawano and coworkers reported, "90% of K562 and 25% of K562/D1 cells underwent erythroid differentiation. The basal expression of glycophorin A in K562/D1 cells was markedly diminished compared with...
Source: Genomics & Genetics Weekly (2004-08-06)
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