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Cervical Cancer
Nucleotide sequencing-based genotyping used to assess HPV disease link in Japan
August 6th, 2004
Researchers in Japan have conducted the first large, case-control study using nucleotide sequencing-based genotyping of cervical cancer risk associated with human papillomavirus (HPV). According to T. Asato and colleagues at the University of Ryukyus in Okinawa, "A consensus primer pair was used to amplify DNA from the L1 region of HPV by polymerase chain reaction (PCR). By PCR, 311 of 356 patients with cervical cancer and 333 of 3,249 control individuals were positive for HPV. By the direct sequencing of PCR products, nucleotide sequences of 30 genotypes were obtained." Among the controls the researchers found a high incidence of HPV type 52 and a...
Source: Genomics & Genetics Weekly (2004-08-06)
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