Genomics & Genetics Weekly
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Depression
ACE polymorphism affects therapeutic outcome in depressed women
August 6th, 2004
The insertion/deletion polymorphism in the angiotensin converting enzyme gene affects the outcome of antidepressant therapy in women, but not men, researchers report. "Angiotensin converting enzyme (ACE) is expressed in the central nervous system (CNS), where its primary function comprises degradation of neuropeptides including substance P (SP). Because of the possible antidepressant effects of SP antagonists, the influence of SP on both pathophysiology and mitigation of depression has been hypothesized," wrote T.C. Baghai and colleagues, University of Munich. Concentration of ACE in plasma "is determined by an insertion/deletion (I/D) polymorphism...
Source: Genomics & Genetics Weekly (2004-08-06)
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