Genomics & Genetics Weekly
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DNA Repair
53BP1 required for class switch recombination
August 6th, 2004
53BP1 is required for class switch recombination "53BPI participates early in the DNA damage response and is involved in cell cycle checkpoint control. Moreover, the phenotype of mice and cells deficient in 53BP1 suggests a defect in DNA repair (Ward et al, 2003b)," researchers in the United States report. "Therefore," wrote I.M. Ward and coworkers, "we asked whether or not 53BPI would be required for the efficient repair of DNA double-strand breaks. Our data indicate that homologous recombination by gene conversion does not depend on 53BPI." The authors continued, "Moreover, 53BPI-deficient mice support normal V(D)J...
Source: Genomics & Genetics Weekly (2004-08-06)
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