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DNA Research
Balanced-PCR facilitates genomic DNA analysis
August 6th, 2004
A "balanced" polymerase chain reaction (PCR) assay facilitates analysis of mildly degraded genomic DNA. "Analysis of genomic DNA derived from cells and fresh or fixed tissues often requires whole genome amplification prior to microarray screening," researchers in the United States noted. "Technical hurdles to this process are the introduction of amplification bias and/or the inhibitory effects of formalin fixation on DNA amplification." To solve these problems, G. Wang and colleagues at the Harvard-associated Brigham and Women's Hospital in Boston devised a "balanced-PCR procedure that allows unbiased amplification of genomic DNA from fresh or...
Source: Genomics & Genetics Weekly (2004-08-06)
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