Genomics & Genetics Weekly
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DNA Research
Microfluidic device suitable for rapid DNA mapping
August 6th, 2004
A novel microfluidic device is suitable for rapid DNA mapping. Researchers in Massachusetts "developed a rapid molecular mapping technology - Direct Linear Analysis (DLA) - on the basis of the analysis of individual DNA molecules bound with sequence-specific fluorescent tags." "The apparatus includes a microfluidic device for stretching DNA molecules in elongational flow that is coupled to a multicolor detection system capable of single-fluorophore sensitivity," explained E.Y. Chan and coauthors at Woburn-based U.S. Genomics. In their study, "[d]ouble-stranded DNA molecules were tagged at sequence-specific motif sites with fluorescent bisPNA (Peptide...
Source: Genomics & Genetics Weekly (2004-08-06)
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