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DNA Research
Mismatch DNA repair heterodimer hMSH2/6 regulates BLM helicase
August 6th, 2004
The mismatch DNA repair heterodimer hMSH2/6 regulates BLM helicase activity. "The human MSH2/6 complex is essential for mismatch recognition during the repair of replication errors," scientists in the United States explained. "Although mismatch repair components have been implicated in DNA homologous recombination repair, the exact function of hMSH2/6 in this pathway is unclear." In their study, O. Yang and coauthors at the National Cancer Institute found that "the recombinant hMSH2/6 protein complex stimulated the ability of the Bloom's syndrome gene product, BLM, to process Holliday junctions in vitro, an activity that could also be regulated by...
Source: Genomics & Genetics Weekly (2004-08-06)
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