Genomics & Genetics Weekly
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Data Mining
Discordant data from microarray platforms make drug research challenging
August 6th, 2004
Discordant data from microarray platforms make drug research challenging. "Many commercial and custom-made microarray formats are routinely used for large-scale gene expression surveys. Here, we sought to determine the level of concordance between microarray platforms by analyzing breast cancer cell lines with in situ synthesized oligonucleotide arrays (Affymetrix HG-U95v2), commercial cDNA microarrays (Agilent Human 1 cDNA), and custom-made cDNA microarrays from a sequence-validated 13K cDNA library," investigators in Finland stated. "Gene expression data from the commercial platforms showed good correlations across the experiments (r = 0.78-0.86),...
Source: Genomics & Genetics Weekly (2004-08-06)
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