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Depression

Zinc stimulates cortical brain-derived neurotrophic factor gene expression

According to a study from Poland, "most antidepressants induce expression of the gene coding for brain-derived neurotrophic factor (BDNF) in the hippocampal/cortical neurons. Recent data indicate antidepressant-like activity of zinc in animal models."

"We now report that chronic treatment with zinc induced an increase in cortical but not hippocampal BDNF mRNA level (Northern blot). Tranylcypromine, a classic antidepressant, increased BDNF mRNA level in both examined brain regions," said G. Nowak and colleagues, Polish Academy of Sciences, Institute of Pharmacology.

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