Genomics & Genetics Weekly
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Drug Development
Critical human skeletal muscle ischemia displays distinct gene patterning
August 6th, 2004
Critical human skeletal muscle ischemia displays distinct gene patterning. "Critical lower limb ischemia is a common cause for amputation. To develop new therapeutic strategies, more information is needed about molecular mechanisms of tissue responses to ischemic stress and factors inducing angiogenesis. Using a DNA array of 8400 genes, gene expression patterns in human skeletal muscle samples collected from lower limbs amputated due to acute-on-chronic or chronic critical lower limb ischemia, were compared with the control samples collected from the same limb," scientists in Finland report. "The results were confirmed by reverse...
Source: Genomics & Genetics Weekly (2004-08-06)
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