Genomics & Genetics Weekly

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Endocrinology

Hormone replacement therapy may protect against colon cancer

"Epidemiological studies show a strong link between post-menopausal hormone replacement therapy and decreased incidence of colorectal cancer. The colon cancer cell line, COLO 205, develops sensitivity to 17beta-estradiol (E₂ ) in apoptosis assays with increasing passage number (>40), and we hypothesized that genes selectively regulated in multiply passaged cells were likely to be important in E₂ -related apoptosis. Gene array analysis was used to compare the patterns of genes up- or down-regulated in E₂ -sensitive and -insensitive cells," scientists writing in the...

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