Genomics and Genetics Weekly

DNA Repair - FANCD2 has direct interaction with BRCA2 in DNA damage response pathways

Genetics - Model for imaging gene expression by trans-splicing described

Genomics and Genetics - Transcription factor AP-2alpha plays key role in trophoblast differentiation

Glaucoma - Effect of hydrostatic pressure on ONH astrocyte gene expression determined

Leishmaniasis - Expression profiling of the Leishmania life cycle conducted

Alzheimer Disease - Pharmaceutical company presents findings on PAN-811 for Alzheimer disease

Alzheimer Disease - Results on biomarkers for early diagnosis of Alzheimer Disease announced

Angiology - Estrogen receptor associated with epithelioid variants of renal angiomyolipoma

Anti-Infectives - Pediatric patients require higher dosages of i.v. voriconazole than adults

Antiretroviral Drug Resistance - Long-term suppression of HIV RNA with HAART occur despite virus evolution

Antiretroviral Therapy -  Clusiaceae species extracts inhibit HIV-1 reverse transcriptase

Antiretroviral Therapy - Addition of tenofovir decreases AUC for atazanavir in HIV-treated patients

Antiretroviral Therapy - Atazanavir suppresses HIV with extended use and in nelfinavir-switched patients

Antiretroviral Therapy - Microglia-expressed MRPs may restrict permeation of antiretroviral drugs

Antiretroviral Therapy - Mutation D30N not selected by HIV-1 subtype C in nelfinavir resistance

Antiretroviral Therapy - Previous immunosuppression predicts incomplete immune reconstitution after HAART

Antiretroviral Therapy - Ribinucleotide reductases attenuate efficacy of abacavir

Antiretroviral Therapy - Sustained HIV virological response better with triple nucleoside therapy

Ariadne Genomics - Metabolic Vision advanced microbial metabolic pathway database launched

Bacterial Resistance - Infection control measures should guide methicillin-resistant S. aureus control

Bacteriology - Homologue of aliB found in capsule region of nonencapsulated S. pneumoniae

Biological Markers - DC-SIGN is a marker for dendritic cells and alternatively activated macrophages

Biomarker Assays - Company launches ProteinChip System, Series 4000

Bladder Cancer -  TRIO upregulated in urinary bladder tumors

Brain Cancer - Childhood brain cancer linked to deletion of a Hedgehog pathway suppressor

Breast Cancer - BRCA2 mutations more important in hereditary disease in Cyprus than BRCA1

Breast Cancer - Gene linked to breast cancer can suppress tumors

Breast Cancer - Steroid sulfatase inhibitors inhibit MCF-7 breast cancer cell gene activation

Breast Cancer - Virtual counselor supplements traditional genetic counseling

Business & Finance - Pharma company releases financial report, business update

Cancer Genetics - Alcohol, but not dietary antioxidants, linked to increased p53 mutation risk

Cancer Genetics - Study examines responses to BRCA1/2 genetic testing of women who've had cancer

Cancer Markers - H3 mRNA level new proliferative marker in astrocytomas

Cancer Therapy - Celera, Seattle Genetics, to co-develop targeted antibody therapies for cancer

Cardiopulmonary Disease - Air pollution increases vasoconstriction in the lungs of rats

Cardiovascular Disease - Panel develops sports guidelines for youth with genetic cardiovascular diseases

Cardiovascular Malformations - Altered transcription occurs in the DiGeorge and Velocardiofacial syndromes

Cervical Cancer - QMSP assay of cervical scrapings has diagnostic potential

Collaborations - Alliance formed to launch clinical pharmacogenomic diagnostics

Collaborations - Companies form alliance to design, validate gene-marker panels

Collaborations - GSK enters partnership to advance development of anti-infective compound

Collaborations - Genome-wide line of RNA assays for gene silencing measurement launched

Congenital Heart Disease - Deletions on chromosome 1q21.1 are related to congenital heart disease

Coronavirus - SARS-associated coronavirus infection inhibited by immoral immune response

Cystic Fibrosis - Domain mimic may help correct protein trafficking defect in CF epithelia

DNA Analysis - Quadruplex regulates expression of c-Myc oncogene, adopts parallel-loop isomers

DNA Microarrays - DNA microarrays used as a tool in toxicogenomics

Diabetes - Affymetrix, Cambridge Univ. and partner collaborate in genetic study of diabetes

Diabetes Genomics & Genetics - PPAR-gamma coactivator-1 variant not associated with diabetes-related traits

Diabetes Genomics & Genetics - Type 1 diabetes susceptibility locus found on chromosome 5q11-q13

Diagnostics - One-step quantitative RT-PCR assay detects SARS coronavirus

Diet and Nutrition - Renal genomic response to low-phosphate diet characterized

Drug Development - Analytic technique facilitates discovery of agents for acute SCI

Drug Development - Milestone met for development of mouse models for Bayer target genes

Drug Development - Pharmaceuticals companies collaborate on cancer therapeutics

Embroyonic Research - Deletion of P450c17 gene causes early embryonic lethality

Environmental Health - Genomic effects of JP-8 jet fuel determined

Epigenetics - Scientists suggest framework for studying common diseases

Evolutionary Biology - Study finds anti-HIV protein evolved millions of years before emergence of AIDS

Eye Health - Medical device company reports clinical trials results of Presbyopia treatment

Finance - Antidepressant maker reports fiscal Q1 earnings of $.60 per share

Finance - Bioscience company reports financial results

Finance - Dental-focused pharmaceutical reports increased revenues, sales

Finance - Drug company reports revenues up for the second quarter of 2004

Finance - NIH renews funding to researchers for rb2 tumor-suppressing gene

Finance - TF decoy technology company reports Q2 milestones, $10.6M revenue

Forensic Medicine - High-performance DNA multilane microdevice system developed

Gastric Cancer - DOG1 ubiquitously expressed in gastrointestinal stromal tumors

Gene Expression - Hepatocyte nuclear factor-1beta-regulated genes identified

Gene Expression - WT1 gene expression studied as marker for minimal residual disease JMML and MDS

Gene Mutation - One-allele inactivation of AML1 has role in development of overt disease

Gene Profiling - Proteomics company acquires rights to DNA modification chemistry patents

Gene Therapy - HSV immortalized T cells are gene therapy model for primary immunodeficiencies

Gene Transfer - Neuroprotective effects PEI-mediated gene delivery described

Genetic Diagnostics - LabOne signs supply agreement with DNA testing company

Genetic Disorder - Rare heart tumors may be more common than thought, researchers say

Genetic Engineering - Traceability of genetically modified organisms in the food chain discussed

Genetics - A novel gene mutation in congenital neuropathy described

Genetics - AAV2-mediated gene therapy may help patients with a form of Batten disease

Genetics - Phase I of Proficiency Testing Program for microarray facilities complete

Genome Variation - New study uncovers large-scale differences in the human genome