Genomics and Genetics Weekly

Cell Biology - DNA and histone synthesis are coordinated under normal and adverse conditions

DNA Research - Effect of biotin on T-cell CYP1B1 expression characterized

Gene Mapping - Marker studies grow closer to identifying a gene for the MRX84 disorder

Gene Research - Gene variants associated with CV disease show no relation to atherosclerosis

Genomics - Klhl may have a role in the organization of striated muscle cytoarchitecture

Acute Renal Failure - Physiologic and transcriptional causes elucidated

Adenovirus Detection - Novel method detects and types adenoviruses directly from conjunctival scrapings

Aging - Overexpression of fatty acid-binding protein related to skin aging

Alcoholism - Study reports genetic susceptibility to alcoholism in NMDA receptor

Alzheimer Disease - Biotech company announces results of Alzheimer study

Alzheimer Disease - Current status of Alzheimer disease genetics reviewed

Antibiotics -  S. warneri ISK-1 gene cluster characterized

Antimicrobial Resistance - Integrons play minor roles in antibiotic resistance in surgical units

Antimicrobials - Baylor, biopharma to test an agent against deadly resistant bacteria

Antiviral Therapy - Adefovir curtails lamivudine-resistant mutants in woodchucks with hepatitis

Bacteriology - Three SNP genotypes in ALDH2 detected using bacterial magnetic particles

Brain Ischemia - Acute and delayed ischemia-induced gene expression characterized in rats

Breast Cancer - Loss of PTEN expression infrequent

Breast Cancer - Ninety-seven grants awarded to breast cancer scientists and researchers

Breast Cancer - PTEN loss in invasive ductal carcinoma of the breast predicts poor survival

Breast Cancer - Promoter methylation of PTEN gene is common molecular change in breast cancer

Breast Cancer - U.S. NIH study seeks 50,000 sisters of women with breast cancer

Business & Finance - Biotechnology company announces commitment for $13 million equity financing

Business & Finance - Gene-identification company provides 2004 update

Business & Finance - Gene-transfer company moves to Nasdaq

Business Update - Diagnostics company joins personalized medicine coalition

Campylobacter - Thermophilic Campylobacter detected by real-time PCR hybridization probe assay

Cancer Therapy - Epigenome manipulation turns off as many genes as it turns on

Cancer Therapy - Imatinib sensitivity predicted by testing Wilms tumor gene expression

Cancer Therapy - Novel transplatinum drug ATZ interferes with topoisomerase I in cancer cells

Cancer Therapy - PTEN deficiency predicts trastuzumab resistance in breast cancer patients

Cardiology - Atrial and brain natriuretic peptide levels rise in the ischemic myocardium

Cardiology - Established methods, new imaging techniques used to study conotruncal defects

Cardiomyocytes - PCM.1 binds primary cardiomyocytes 180 times better than control phage

Cardioprotection - Trans-resveratrol suppressed aortic atherosclerosis and reduced thrombosis

Cell Biology - Yeast centrin Cdc31 linked to nuclear mRNA export machinery

Cerebrovascular Atherosclerosis -  Chlamydia pneumoniae not involved in severe cerebrovascular atherosclerosis

Cerebrovascular Disease - Global ischemia produces gene clusters that can index stress severity

Chondrogenesis - ZNF470 may help regulate chondrogenesis-specific gene expression

Chronic Liver Disease - Hepatitis C virus NS5A and nuclear factor-kappa B generate liver injury

Chronic Myeloid Leukemia - BCR-ABL transcripts early predictors for hematological relapse in CML after HSCT

Clinical Practice - Full participation minimizes parallelisms and gaps between research and care

Collaborations - Althea enters alliance to expedite genomic biomarker identification, application

Collaborations - GNI enters R&D drug-discovery collaboration

Collaborations - Partnership to allow hospital and university system to share resources

Collaborations - SAIS and CombiMatrix to jointly develop biothreat identification microarrays

Coronary Artery Bypass Grafting - Effects of enalapril, losartan, and/or IL-6 gene mutations determined

Cushing Syndrome - GIPR regulatory genes are unlikely to underlie GIP-dependent Cushing syndrome

Cystic Fibrosis - Foundation urges states to include CF screening for newborns in test panels

Cystic Fibrosis - Positive phase II results reported for cystic fibrosis drug

Cytokines - Single nucleotide polymorphisms in cytokine genes genotyped

DNA - Photo film company enters nucleic acid market

DNA Research - Incubation temperatures facilitate DNA hairpin structure reopening

DNA Research - Novel reaction discovery technique developed

Dermatology - Multiple loci are responsible for causing Marie Unna hereditary hypotrichosis

Dermatology - Stat3 is required for the onset of epithelial carcinogenesis

Diabetes Complications - Gene linked to greater risk of heart disease in type 2 diabetes

Diabetes Genomics and Genetics - Lymphocyte-specific protein tyrosine kinase gene and diabetes analyzed

Diabetes Genomics and Genetics - UCP2 gene promoter polymorphism modulates lipids in diabetic patients

Diabetes Pathogenesis - Progression to islet destruction in transgenic model reviewed

Diabetes Risk Factor - HLA class I molecules on T cells overexpressed in type 1 diabetes

Diabetic Nephropathy - Human GFPT1 gene associated with diabetic nephropathy

Diagnostics - Antitumor response visualized by fluorescent molecular tomography

Diagnostics - Bioassays company announces U.S. Army contract, new kinase Activity Assays

Diagnostics - Prevalence of Porphyromonas gingivalis associated with periodontal status

Diagnostics - Surfactin-producing Bacillus subtilis rapidly detected and characterized by PCR

Diagnostics - Tabletop DNA test laboratory developed

Diet & Nutrition - Excess dietary omega 6 speeds breast cancer by altering gene activity

Distribution Agreement - Cold Spring Biotech Corp. to distribute avadis in Taiwan

Down Syndrome - Researchers review inhibin A in second-trimester screening

Drug Development - NIH agency awards $6 million contract for preclinical studies on drug addiction

Drug Resistance - Oligonucleotide chips detect mutants in untreated patients with hepatitis B

Embryology - Embryotrophic effect of PAF mediated via functional receptors in SCNT embryos

Endocrinology - Real-time PCR simultaneously analyzes numerous steroidogenic enzyme expressions

Endocrinology - Study reports positive correlation between allopregnanolone and PBR density

Environmental Health - Molecular effects of different types of estrogen clarified

Finance - $9 Million funding round closed

Finance - Bioinformatics company secures EUR 2.25M growth financing

Finance - Biotech listed as one of Maryland's fastest-growing technology companies

Finance - Biotech reports third quarter revenue increase of 64%

Finance - Encore offers stock option grants to employees of acquired company

Finance - Photodynamic therapy company receives $15 million line of credit

Finance - Regeneration-focused company to raise $13.2M in registered direct offering

Gene Expression - Transgene expression endures under the right conditions

Gene Expression - Updated E. coli and Yeast whole genome arrays launched

Gene Linkage - Linkage studies refine the association of MAPT and Parkinson disease

Gene Mutation - Mutation hotspots in p53 gene depend on tumor type and cell growth conditions

Gene Research - Somatic mutations in genes of cardiac cells provide a novel mechanism of disease

Generalized Anxiety Disorder - New data suggest Cipralex is superior to Paxil for GAD

Genetic Disorders - Bed partner ratings provide added information in sleep disordered breathing

Genetics - Close parallel is seen between D. melanogaster and mammalian mesoderm

Genomics - Companies team up to provide researchers human genomic DNA for gene regulation

Genomics - Genomics company and GlaxoSmithKline sign agreement for genome scanning project

Genomics - Genomics company taps Wilson Sonsini Goodrich & Rosati as law firm

Genomics and Genetics - Chromatin architecture of human genome characterized

Genomics and Genetics - Imaging programs developed for E. coli microarray studies

Genomics and Genetics - Utility of BAC arrays reviewed

Genomics and Genetics - Utility of microarrays in cytogenetic analysis reviewed

Geriatrics - Alterations in MCP-1 may influence the pathology of Alzheimer disease

Geriatrics - Genes may have a greater influence on longevity as one grows older

Gingivitis - Long-term cyclosporin A exposure suppresses cathepsin-B/-L in gingival cells

Gum Disease - Laser gum-disease protocol gains FDA clearance

HIV/AIDS Diagnostics - Cobas Amplicor HIV Monitor 1.5 test modified to measure proviral DNA in PBMCs

HIV/AIDS Drug Resistance - Multidrug-resistance in primary HIV infection leads to superinfection

HIV/AIDS Drug Resistance - Primary drug resistance persists in recently HIV-1 infected adults

HIV/AIDS Pathogenesis - Inducible iNOS CCTTT-repeat polymorphism not associated with HIV pathogenesis

HIV/AIDS Research - Novel CCR5 mutation affects HIV co-receptor immunoreactivity/fusogenic property

HIV/AIDS Research - Structure of HIV-1 genomic RNA in gp120 gene determines a recombination hot spot