DNA Research
Effect of biotin on T-cell CYP1B1 expression characterized
Published in Genomics and Genetics Weekly, November 12th, 2004
"DNA microarray studies provided evidence that biotin supplementation increases the abundance of mRNA encoding cytochrome P450 1B1 (CYP1B1) in human lymphocytes," scientists in the United States explained. "CYP1B1 hydroxylates procarcinogens, generating electrophilic mutagens."
In their study, R. Rodriguez-Melendez and coauthors at the University of Nebraska "sought to identify the signaling pathways that increase the expression of CYP1B1 in biotin-supplemented human T (Jurkat) cells and to determine whether activation of the CYP1B1 gene is associated with...
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