Genomics and Genetics Weekly

HIV/AIDS Microbicide - Mannose-specific plant lectins are microbicidal against HIV-1

HIV/AIDS Pathogenesis - RA signaling contributes HIV latency establishment in monocytes/macrophages

HIV/AIDS Research - Endogenous RT activity is the best surrogate measure of infectious HIV-1 titer

HIV/AIDS Research - Genetic variants of APOBEC3G accelerate HIV-1 disease progression

HIV/AIDS Research - HIV-2 Gag interacts with PRP4 and inhibits phosphorylation of splicing factor 2

HIV/AIDS Research - Hsp16 inhibits HIV-1 by suppressing Vpr-specific activities

HIV/AIDS Research - Interactions between hnRNP A2 and HIV-1 A2REs influence HIV-1 gene expression

HIV/AIDS Research - Lentiviral cDNA library used to clone HIV-1-induced cell death inhibitor

HIV/AIDS Research - Reemergent R5 HIV more closely related to its predecessor than to X4 strains

HIV/AIDS Research - Unintegrated HIV-1 DNA participates in virus replication

HIV/AIDS Therapy - CXCR4 inhibitor AMD3100 has side effects/does not decrease HIV viral load

HIV/AIDS Therapy - HIV-1 protease inhibitors block TLR2 and TLR4-induced NF-kappa B activation

HIV/AIDS Therapy - Indinavir impairs protein synthesis and phosphorylations of MAPKs in myocytes

HIV/AIDS Therapy - Mega-HAART causes rapid HIV decay in HAART-experienced children

HIV/AIDS Therapy - New class of NNRTIs are highly microbicidal against HIV-1

HIV/AIDS Therapy - Not all antiretroviral medications cross the blood-testis barrier

HIV/AIDS Therapy - Risk of virologic failure with LPV/r increased in children pretreated with PIs

HIV/AIDS Treatment - Study of drug's effects in antiretroviral nonresponding HIV infections published

Haemonchus Vaccine -  Haemonchus protease mRNA sequences are extremely abundant and diverse

Headaches - Enrollment completed in clinical trial of migraine treatment in triptan users

Hematology - Uniparental isodisomy defines the origins of an afibrogenemia proband

Hepatitis - PEGASYS combination therapy eradicates hepatitis C in 50% of "healthy" carriers

Hepatitis C Virus Therapy - Combination therapy containing ribavirin generates HCV RNA mutagenesis

Hepatology - Liver site-specific gene transfer generates protein in murine models

Hyponatremia - U.S. FDA grants approval for investigational drug to treat hyponatremia

Imaging - Technology company introduces ImageChecker DMax CAD

Immunology - Genes with altered expression in thymocyte positive selection identified

Inflammation - Mesangial pro-inflammatory genes analyzed, inhibition revealed

Inflammation - Poly(ADP-ribose) polymerase-1 guides inflammatory response in mice

Intestinal Cancer - Epiregulin deficiency does not alter intestinal cancer susceptibility

Kaposi Sarcoma-Associated Herpesvirus - Defective KSHV is present in KS tumors and primary effusion lymphoma cells

Kaposi Sarcoma-Associated Herpesvirus - KSHV latent nuclear antigen disruption leads to abortive episome persistence

Kidney Disease - RNA targeting Fas protects mice from renal ischemia-reperfusion injury

Legal Issues - Biosciences company wins $14.2 million arbitration award

Licensing Agreement - Dyax grants use of its antibody phage display libraries for antibody development

Listeria Monocytogenes -  L. monocytogenes isolates form distinct but overlapping populations

Liver Disease - Gene transfer procedures may correct inborn liver metabolism disorders

Lung Cancer - Potential genetic biomarkers of NSCLC identified

Marfan Syndrome - Renal phenotype characterized in a mouse model of Marfan syndrome

Mental Health - Effects of chronic CRF overexpression determined in mice

Metabolic Syndrome - UCONN, personalized medicine company, collaborate on obesity, metabolic syndrome

Miscarriage - Gene defect may be a cause of miscarriage

Multiple Sclerosis - Genetic targets of methylprednisolone therapy identified

Multiple Sclorosis - Relapsing multiple sclorosis treatment approved by U.S. FDA

Mutagenesis - Concurrent gene and protein analyses expose p53 status in liver cancer patients

Mutagenesis - HLA-E polymorphism may contribute to the formation of nasopharyngeal carcinoma

Mutagenesis - New splice site mutations in the WAS gene cause Wiskott-Aldrich syndrome

Mutagenesis - Proteolipid protein 1 gene point mutations convey spastic paraplegia 2 severity

Mycobacteria - Novel mycobacterium isolated from patients with febrile syndrome

Nanotechnology - Diagnostic products developer funds nanotechnology research

Nanotechnology - Scientists embed computation in a DNA crystal to create microscopic patterns

Neurodegeneration - Early onset Alzheimer disease maps to the T/T genotype of interleukin-1

Neurodegeneration - Essential fatty acids may slow Huntington disease progression

Neurodegenerative Disease - The function of synuclein in the etiology of Parkinson disease is an enigma

Neurology - Chromosomal clustering defines the genetic character of forebrain structures

Neurology - HT2A receptor polymorphism destabilizes signaling

Obesity - Forecast: New drug could be safer for treating obesity than previous drugs

Obesity - Pharma company expands research scope to include obesity and diabetes

Obesity - Survey finds Americans believe obesity treatment should be included health plans

Obesity Genomics and Genetics - Murine body weight QTLs, Bwq1 and Bwq2, characterized

Obesity Genomics and Genetics - QTL affecting body mass in mice identified

Obesity Genomics and Genetics - Two ancestral forms of neuromedin U-2 receptor gene reported

Obesity and Diabetes - proopiomelanocortin gene polymorphism linked to insulin in obesity

Occupational Health - Genetics affect coke-oven worker susceptibility to chromosomal damage

Oncology - Mechanisms of tumor suppressor RASSF1A elucidated

Oncology - Pharma companies announce oncology therapeutics research milestone

Ophthalmology - Antisense oligonucleotides focus on the control of ocular angiogenesis

Organ Transplantation - Riverdale woman shares kidney with baby sitter's daughter

Osteoporosis - Association examined between TNFRSF1B polymorphisms and BMD

Osteoporosis - Foundation endorses Surgeon General's report on osteoporosis

Osteoporosis - Pharma company expands scope of new drug application PREOS

Osteoporosis - Software developer includes osteoporosis testing on MicroDose Mammography system

Ovarian Cancer - Potential ovarian cancer susceptibility allele of low penetrance identified

Pain Research - Utility of microarrays and laser capture microdissection reviewed

Pancreatic Cancer - Putative amplification target genes identified

Parkinson Disease - Alpha- and beta-synucleins analyzed, deletion affects synaptic functions

Parkinson Disease - Neuromelanin inhibits proteosome activity in dopamine neurons

Parkinson Disease - Proteasome inhibition sensitizes dopamine neurons

Patents - Maker of microarrays for genomic research gets patent for dispensing technology

Patents - SynX granted key European patent for stroke diagnostics

Pediatrics - Genes have a significant influence on pubertal changes in youth

Peptide Synthesis - Calcitonin-gene regulated peptide and regenerating sensory axons investigated

Periodontal Disease - NIDCR launches unique initiative on oral biofilm

Personnel - Biotech company names vice president of sales

Personnel - Biotechnology company announces new board member

Personnel - DNA analysis company appoints CEO

Personnel - Dr. Steven Nissen named chairman of medical and scientific advisory board

Personnel - Graham Dixon joins genomics company as CSO

Personnel - H. Thomas Watkins appointed CEO

Personnel - Paul N. Lucas appointed chairman of genetics-focused biosciences company board

Pharmacokinetics - Pharmacokinetic variability of metoprolol in metabolizers of CYP2D6 was large

Philanthropy - Moyer Foundation donates $1.5 million for early-detection cancer research

Physiology - Activated hypoxia-inducible factor boosts angiogenesis in ischemic muscles

Prions - Trimethylamine N-oxide prevents prion misfolding

Prostate Cancer - Metastatic hormone-refractory prostate cancer treatment trial results reported

Protein Regulation - Electrical signals stimulate proteins that heal orthopedic injury or arthritis

Proteomics - GSK3 has multiple regulatory roles in Dictyostelium development

Reproductive Biology - Enzyme discovered that generates egg-protecting hydrogen peroxide

Reproductive Medicine - ET-1 and NO production characterized in luteal endothelial cells

Rheumatoid Arthritis - Premature stem cell aging provides basis for immune-mediated tissue damage in RA

SARS - ACE1 polymorphism may influence progression of pneumonia in SARS

Skin Cancer - p53 point mutation at Ser389 increases sensitivity to UV radiation

Spinal Muscular Atrophy - Survival motor neuron protein isoforms characterized

Stem Cell Research - Amnion mesenchyme cells express phenotypes of neuroglial progenitor cells

Stem Cell Research - Creating $3 billion stem cell agency no small feat

Stem Cell Research - Distinct cell "side population" has high drug efflux capacity in tumor cells

Stem Cell Research - Downstream genes of ascidian muscle determinant gene Ci-macho1 identified

Stem Cell Research - Lentiviral vectors funnel genes into neural stem cells for therapeutic use

Stem Cell Research - Tel/Etv6 is essential and selective regulator of adult HSC survival

Stress - NF-kappaB, evoked by psychosocial stress, may directly target vessels, kidneys

Survival and Mortality - VEGF-A expression is a prognostic marker for angioimmunoblastic T-cell lymphoma

Transfection - Electroporation-assisted gene transfer yields gene expression in murine muscles

Transfusion Medicine - Paper: RhAG plays key role in maintaining pH balance in red blood cells

Transplant Medicine - Research sets gestational window for harvesting porcine fetal pancreatic tissue

Tularemia Vaccine -  Francisella tularensis genes encoding membrane-associated proteins identified

Vaccine Development - Genome-based vaccines reviewed

Varicella Zoster Virus Infection - Severe abdominal pain is important sign of VZV infection in SCT recipients

Vascular Development - Notch activation is essential for embryonic vascular remodeling

Viral Genomics - Geographical differences sway the unique variations of hepatitis B subtypes

Viral Vectors - Optimized inducible vectors improve transfection and transgene expression

Virology - Lentiviral transduction of cord SCs yields high-level beta-globin expression