Genomics and Genetics Weekly

Adenovirus Vaccine - Human adenovirus 4 genome characterized

Cell Biology - Scientists develop promising new assay for studying cancer-causing breaks in DNA

Gene Promotion - E2F transcription factors mediate oncoprotein 18 activity in prostate cancer

Genetic Research - Method is proposed for investigating link between polymorphic gene and phenotype

Genomics -  D-p38a gene is needed to mediate some functions of p38 signaling

Acute Myelogenous Leukemia - Farnesyl transferase inhibitor can help patients at high-risk for AML

Addiction Medicine - Many hepatitis B virus-infected intravenous drug users carry mixed genotypes

Alcoholism - Genetic influences on taste perception of alcohol may influence alcohol intake

Allergy and Immunology - Biological loading of allergens different due to local influences

Alzheimer Disease - Dihydrolipoamide dehydrogenase gene associated with Alzheimer disease

Alzheimer Disease - Kinetic models of urea modulation of beta-amyloid fibril growth studied

Alzheimer Disease - M1 muscarinic receptor activation role studied in beta-amyloid toxicity

Alzheimer Disease - Mutations in APP studied, effects on A beta and CTF gamma generation revealed

Angiotensin - Study looked for association of ACE gene polymorphism with other parameters

Antisense Technology - Genomics firm updates third-generation Neugene antisense program

Apoptosis - Tula hantavirus infection induces caspase-mediated apoptosis

Asthma - VEGF is overexpressed in the nasal polyps of asthmatic patients

Autism - Autism assessment company, Cure Autism Now join to identify disease biomarkers

Avian Sarcoma Virus - ASV integration sites in human genome distributed over all chromosomes

Bone Marrow Disorders - Discovery of genetic profiles, mutations aid treatment of bone marrow disorders

Bone Mineral Density - Volumetric bone mineral density is heritable trait

Breast Cancer - Docetaxel regimen for early stage breast cancer significantly improves survival

Breast Cancer - First international registry of early stage breast cancer patients launched

Breast Cancer - Hexadecylphosphocholine causes rapid cell death in mammary tumor cells

Breast Cancer - Study suggests ability to distinguish good and bad breast cancer prognosis

Business Update - Biosciences company announced research collaboration with LifeScan

Business Update - Company awarded second Medicare contract to prevent disease progress

Business Update - License agreement for platinum-containing, anticancer drug candidates

Business and Finance - Galileo Genomics raises $11M in equity financing, changes name

Business and Finance - MYODUR maker announces completion of reverse merger

Business and Finance - Pharma company announced dividend

Business and Finance - Pharma company offers financial results

Calcivirus Infection - Histological features of calcivirus infection overlap with allograft rejection

Cancer Diagnosis - BJ-HCC-20 may be a potential novel cancer-testis antigen

Cancer Genetics - Association studied between breast density and estrogen-linked gene variants

Cancer Genetics - PIK3CA is an oncogene in ovarian cancer, common mutation in early breast cancer

Cancer Metastasis - Fossil record shows antibodies that block cancer metastasis

Cancer Research - Genomics company invents technology for diagnosis and prognosis of cancer

Cancer Research - Trial of Combretastatin A4 Prodrug with carboplatin and paclitaxel initiated

Cancer Therapy - APC8024 immunotherapy shows promise in advanced breast cancer

Cancer Therapy - Additional phase II clinical trial launched for lead cancer drug candidate

Cancer Therapy - Company acquires c-myb antisense drug from Temple University

Cancer Therapy - Hypersensitivity to low-dose radiation associated with p53-dependent apoptosis

Carcinogens - Different genotoxic mechanisms for lung cells exposed to chromate particles

Cardiac Devices - First European commercial implant of aortic stentless tissue valve performed

Cardiology - Brain injury after cardiac surgery studied, role of apolipoprotein clarified

Cardiology - Definition of cardiomyopathies should be broader

Cardiology - Studies report high incidence of cognitive decline following artery bypass

Cardiovascular Disease - Survey shows heart disease risk factors are not aware of coronary event risk

Cell Therapy - Company announces article describing its ACE System

Chemotherapy - Study results demonstrate breast cancer assay predicts chemotherapy response

Chronic Lymphocytic Leukemia - Combination of MabCampath and Fludara shown to be highly effective in CLL

Collaborations - Companies to develop cell lines for production of recombinant proteins

Collaborations - Genzyme enters gene-therapy collaboration

Colon Cancer - DNA testing for colon cancer may not be a magic bullet

Colorectal Cancer - DNA test for colorectal cancer yields disappointing results

Congestive Heart Failure - Gene mutations point to possible role of protein involved in muscle contraction

Coxiella Burnetii - Overall C. burnetii growth cycle characteristic of a closed bacterial system

Crimean-Congo Hemorrhagic Fever - MRNA segment of Crimean-Congo hemorrhagic fever virus outbreak strains analyzed

Cystic Fibrosis - Combined stem cell-gene therapy approach seen as potential treatment

Cystic Fibrosis - Marine biotechnology product offers promise as cystic fibrosis treatment

Cystic Fibrosis - The underlying causes of inherited lung disease uncovered

DNA Research - Novel microfluidic chip system suitable for single-cell analysis

DNA Research - Radiation-induced bystander response causes DNA double strand breaks

DNA Research - Regulation of DNA repair genes by growth stimulation characterized

Dementia - Protein might be a useful biomarker for differentiation between dementias

Dengue Fever - Human leukocyte antigen DQ1 positively associated with dengue fever

Developmental Biology - Abnormal liver development studied, deletion of murine Smn exon 7 implicated

Diagnostics - Company acquires rights from McGill University to breast cancer markers

Diagnostics - Company launches its new Internet-based remote-access program

Dietary Supplements - UK Food Standards Agency says chromium picolinate is safe dietary supplement

Disease Associations - VDR variants may be factors for CVD and bone loss in Mexican American women

Drug Development - Bone therapeutics company announces bone therapy evaluation group

Drug Development - Cells expressing artificial complementary peptide inhibit HIV-1 infection

Drug Development - Hinnuliquinone inhibits HIV-1 protease

Drug Development - Mitochondrial membrane potential disruptor compounds attenuate Lv1 activity

Drug Development - Novel anti-HIV drug design strategy combats susceptibility to drug resistance

Drug Development - Novel targets identified for HIV-1 treatment

Drug Development - Pharma companies select development candidate for inflammation

Drug Development - Pharmaceutical company seeks global regulatory approval of antibiotic

Drug Development - Thermodynamics elucidated for next-generation protease inhibitor TMC114

Ecology - Microbe's genome promises insight into earth's carbon, sulfur cycling

Electron Paramagnetic Resonance - Report presents method to define reactions that occur in spin-trapping process

Embryonic Stem Cell Research - ESC-derived mouse macrophages is an improved model to study vascular disease

Endocrinology - Pleiotrophin is key regulator of renin-angiotensin system in mouse aorta

Enterovirus - Two proposed new enterovirus serotypes, EV74 and EV75, characterized

Environmental Health - Genomic effects of dietary phytoestrogens determined in lab rats

Enzymology - Deregulated catalase stems the growth of p53-defective cells

Escherichia Coli - Novel protein ensures timely initiation of E. coli chromosome replication

Eye Health - Drug application approved for anti-inflammatory/antibiotic combination product

Familial Hypercholesterolemia - Cascade genetic screening for hypercholesterolemia leads to health benefits

Finance - Genetics-focused company reports positive Q1 results

Finance - Infectives-focused biotechnology company announces $20 million private placement

Finance - Maker of receptor-targeted therapeutics completes $22.6M financing

Finance - Medical device company announces $5 million line of credit for general needs

Forensics - New differential extraction tool completes process faster

Fragile X Syndrome - Fragile X gene negatively regulates neuron growth and synaptic differentiation

Gastric Cancer - RNA interference reverses multidrug resistance in gastric carcinoma cells

Gastroenterology - Biliary dysgenesis in a model of recessive polycystic kidney disease studied

Gaucher Disease - Altered glucocerebrosidase may contribute parkinsonism risk in Gaucher Disease

Gene Expression - Genomics-based chip test tool demonstrates 86% accuracy in identifying TUOs

Gene Polymorphisms - MAO-A gene polymorphisms associated with panic attacks and GAD

Gene Profiling - Translationally controlled tumor protein levels decline in tumor revertants

Gene Research - UC Irvine researcher confirms pharmaceutical company's ACE is aging gene

Gene Sequencing - Gene synthesis gets cheaper

Generic Drugs - Pharma company granted ISO certification, approval to market generic Fluoxetine

Genetic Research - Genetic polymorphisms jointly influence renal function

Genetic Testing - European laboratory licenses DNA probe technology to Osmetech

Genetic Testing - Rapid prenatal diagnosis by QF-PCR detects major numerical chromosome disorders

Genomics - Biosciences company announces distribution agreement for DNAWitness

Genomics - Gene therapy company announces agreement, spinal muscular atrophy trial results

Genomics - Intercellular adhesion molecule gene variations discovered

Genomics - New mouse genome oligo set for spotted gene expression arrays now available

Genomics and Genetics - High-performance random microarray devised for quantitative gene profiling

Genomics and Genetics - Insulin-like growth factor genotype affects muscle performance

Genomics and Genetics - RNA amplification improves microarray analysis of tissue samples

Glioblastoma - MXI1-0 is overexpressed in glioblastomas

HIV/AIDS - Phase 2 trial of HIV maturation inhibitor drug announced

HIV/AIDS Pathogenesis - APOBEC3G exploits RNA packaging to infiltrate HIV-1 particles

HIV/AIDS Pathogenesis - Amino-terminal region of HIV-1 nucleocapsid required for APOBEC3G packaging

HIV/AIDS Pathogenesis - Close relationship between HIV-1 phenotypic changes and HIV pathogenesis

HIV/AIDS Research - AA insertions near gag cleavage sites restore activity of mutant protease

HIV/AIDS Research - Alpha-defensins inhibit/augment HIV replication by mechanisms that precede RT