Genomics and Genetics Weekly
Susan Hasty, Publisher
Table of Contents . . . February 25th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Genomics and Genetics Weekly | Other Publications
Alzheimer Disease - Presenilin-1 and gamma-secretase studied, role of fatty acids revealed
Cardiology - Researchers provide details of new studies and findings in the area of cardiology
Genomics - Polymorphism might contribute to increased risk of coronary artery disease
Genomics - ST2LV is a new soluble secreted variant of the ST2 gene product
Genomics - Study identified biochemical and genetic defect in L-2-hydroxyglutaric aciduria
Lipid Studies - Database contains results from whole-genome scans of lipid-related phenotypes
Acute Myeloid Leukemia - Elevated AFlq gene expression is an independent adverse prognostic factor in AML
Acute Myeloid Leukemia - MNK1 is target of several leukemogenic fusion proteins
Acute Myeloid Leukemia - Multiplex PCR profiles minimal residual disease gene expression in AML
Alcohol Use - Genes influence adolescent alcohol consumption
Alzheimer Disease - Pharma company announces interim data for proof of principle study of PYM5008
Amyotrophic Lateral Sclerosis - New findings in the area of amyotrophic lateral sclerosis detailed
Aneurysm - Recognizing new aneurysm syndrome can save lives
Angiology - Arterial tortuosity syndrome is characterized by connective tissue abnormalities
Angiology - Overexpressed RasGRP3 gene may aggravate normal vascular development
Angiology - Recent findings in angiology described
Antibiotic Resistance - Quantitative PCR is a reliable method for determining antibiotic susceptibility
Antidepressants - Effects of imipramine and citalopram on cortical gene expression determined
Antimicrobial Resistance - Bayesian model predicts risk of emerging resistance to antimicrobials
Apoptosis - MKP-1 induction by proteasome inhibitors plays an antiapoptotic role
Apoptosis - NAC enhances hypoxia-induced apoptosis through NfkappaB inhibition
Apoptosis - Rho/rhotekin-mediated NF-kappa B activation confers resistance to apoptosis
Apoptosis - Sox4 CD is a pivotal pro-apoptotic domain to induce apoptotic cell death
Apoptosis - TRAF6 essential in mediating p75 signal transduction/apoptosis induction
Asthma - Company reports success in phase I studies on its GRC 3886
Awards - Foundation announces recipients of annual Wiley Prize in Biomedical Sciences
Awards - Harvard-Partners genetics center scientist wins society's American Medal
Biochemistry - Optimal aptamer assays require individualized assembly
Biotechnology - Microchip system enables continuous monitoring of RNA enzyme reactions
Bioterrorism - Company receives purchase orders for GeneXpert Modules
Bladder Cancer - 9p21 aberrations induced by tobacco smoke associated with bladder cancer risk
Brain Cancer - Gene used in brain development can cause childhood brain cancers
Breast Cancer - Acetyl-CoA carboxylase alpha gene is not a major cause of susceptibility
Breast Cancer - Aurora A Ile/Ile genotype significantly associated with breast cancer risk
Breast Cancer - CYP1A1 gene modifies the relation between PCB exposure and breast cancer risk
Breast Cancer - Cytologic tumor smears provide suitable CISH samples
Breast Cancer - Effect of ionizing radiation on nuclear proto-oncogenes determined
Breast Cancer - Gene expression of invasive primary mammary tumor cells characterized
Breast Cancer - Stat5 protein inhibits spread of breast cancer cells
Breast Cancer - Study: Femara provides survival advantage vs. tamoxifen in adjuvant treatment
Business & Finance - Biotech company relocates to Colorado from U.K., hires James Bruce as CEO
Business & Finance - Infectious disease-focused Chinese biotech company reviews 2004 accomplishments
Business & Finance - Pharma company presents second quarter financial results, product update
Business & Finance - Technology-focused venture group announces investment in Thermal Gradient, Inc.
Business Update - Company announces launch date for Macugen (pegaptanib sodium injection)
Business Update - Drug discovery company announces PharmaCarta agreements with Pfizer
Business Update - GenData changes name
Business Update - Medical device company extends contract to supply hemostatic bandages
Business Update - New version of human genome survey microarray released
Business Update - Nutraceutical company announces partnership with Planta Analytica
Business Update - Oligo-based DNA microarray technology provider launches new service
Business Update - Pharma companies collaborate to develop new antibody therapeutics
Business Update - Research companies execute commercialization agreement
Business Update - VNS developer submits response to FDA warning letter
Cancer Prevention - Citrus fruit consumption positively associated with GST enzyme activity
Cancer Therapy - DAVANAT and DAVANAT/5-FU are well-tolerated by patients
Cancer Therapy - FDA grants orphan drug designation to TOCOSOL Paclitaxel in urothelial cancer
Cancer Therapy - Gene sets are indicted in glucocorticoid-induced leukemic cell death
Cancer Therapy - Phase III data shows Tarceva plus gemcitabine significantly improves survival
Cancer Therapy - RNAi may be effective against viral-mediated oncogenesis
Cancer Therapy - Small molecule inhibitors alleviate epigenetic silencing and drug resistance
Cardiac Development - Periostin is predominantly expressed in endothelium of ventricular trabeculae
Cardiac Hypertrophy - Normal cardiac growth may be cofactor in development of genetic cardiomyopathies
Cardiac Hypertrophy - Stress from long-term hypertrophy may cause myocytes to reenter the cell cycle
Cardiology - Cardiovascular device company comments on HeartMate II clinical study filing
Cardiology - New findings impact diagnostic, therapeutic strategies of sudden death syndromes
Cardiology - The causes of inflammation in dialysis are multifactorial
Cardiovascular Research - Fatigue is associated with CV disease, may not be influenced by genetic factors
Cell Biology - Key mechanism in genetic inheritance during cell division identified
Cervical Cancer - Histidine triad gene intron 5 linked to severe cases
Chemotherapy - Doxorubicin inhibits DNMT1 and results in conditional apoptosis
Chronic Kidney Disease - CRP monitoring in chronic kidney disease deserves closer study
Chronic Lymphocytic Leukemia - Constitutive expression of MMP-9 dependent on p38-activity
Clinical Trials - Company to provide microarray-based genomic data for ITN trials
Clinical Trials - Neuro-inflammatory disease drug approved for phase 1 clinical development
Collaborations - Joint stem-cell research program launched
Collaborations - Pharmaceutical companies agree to jointly commercialize oral cancer drug
Collaborations - Pharmaceutical companies announce collaboration on osteoporosis treatment
Colon Cancer - APC E 1317Q/I1307K germ-line variants not detected in sporadic colon cancer
Colon Cancer - GADD153 protein may be important for curcumin-induced apoptosis
Colon Cancer - Mouse models reveal a novel key player in the initiation of cancer
Colon Cancer - Novel gene CLUAP1 may be biomarker or therapy target
Colon Cancer - Research in colorectal cancer presented at symposium
Colorectal Cancer - Avastin plus FOLFOX4 chemotherapy regimen clinical trial results reported
Colorectal Cancer - Biallelic/monoallelic MYH gene mutations associated with colorectal cancer risk
Colorectal Cancer - Functional polymorphism in E-cadherin gene associated with colorectal cancer
Colorectal Cancer - PUMA expression changes of minor importance in colorectal cancer development
Coronary Artery Disease - The eNOS 4a/b polymorphism does not have a major impact on CAD
Cryptosporidium Parvum - Two Cryptosporidium parvum genotypes caused recreational water outbreak
DNA Repair - Hef protein uses dual mechanisms to jumpstart stalled replication forks
Diabetes Genomics and Genetics - Cytotoxic T lymphocyte antigen gene linked to type 1 diabetes
Diabetes Genomics and Genetics - Genetics of type 1 diabetes reviewed
Diabetes Genomics and Genetics - MTH1 gene polymorphism linked to type 1 diabetes in Japanese females
Diabetes Pathogenesis - Gene polymorphisms predict development of type 2 diabetes
Diabetes Pathogenesis - Recent findings illuminate research in diabetes pathogenesis
Diabetes Pathogenesis - Reports add new data to diabetes pathogenesis research
Diagnostics - Blood tests might eliminate tissue extractions in leukemia, lymphoma patients
Diagnostics - FDA approves gene-based test for hematuria patients' bladder cancer
Diagnostics - Foundation organizes campaign for genetic test that screens for 11 diseases
Diagnostics - Optical images capture gene expression in the arteries
Diagnostics - Quantitative biofilm assay/plate screens enteroaggregative E. coli
Diagnostics - Skin sterol test available for sale in Canada, U.S. markets
Diet & Nutrition - IntegraGen to participate in Diet, Obesity and Genes project
Diet & Nutrition - Metabolic adaptation to high-fat diet linked to lipid fluxes in liver
Disease Associations - Alpha-synuclein studied, distribution and Lewy body relationship revealed
Disease Associations - Batten disease studied, requirements for targeting of CLN3 protein clarified
Disease Associations - Prefrontal cortex studied, influence of nicotine and smoke exposure revealed
Disease Associations - Prion protein toxicity studied, translocation-medicated protection revealed
Disease Associations - Structure of LIS1 analyzed, complex with PAF-acetylhydrolase shown
Drug Development - Biopharmaceutical company initiates trials for antidepressant
Drug Development - HIV/HTLV-1 protease inhibitors and antimalarial compounds developed
Drug Development - Pathway profiler service for viewing cellular responses introduced
Drug Development - Random mutagenesis creates deaminases with gene therapy potential
Drug Metabolism - Seven variant CYP4F12 allozymes characterized
Duchenne Muscular Dystrophy - Biopharma company granted orphan drug designation by FDA for PTC124
Electrophoresis - Electrokinetic supercharging enables high-sensitivity DNA detection
Electrophoresis - Novel chip injection technique improves high-resolution DNA separation
Embryonic Stem Cell Research - Wnt11 facilitates ESC differentiation to Nkx2.5-positive cardiomyocytes
Embryonic Stem Cell Research - Zap3 overexpression reduces telomerase activity during ESC differentiation
Emphysema - Gene expression in emphysema lung tissue characterized
Endocrinology - Hormonal differences direct the human urate transporter gene promoter
Endometrial Carcinoma - Influence of PTEN mutations on outcome determined
Endothelial Cell Production - Ursodeoxycholic acid inhibits endothelin-1 production in vascular endothelium
Environmental Exposure - Industrial residues from household-wax manufacturing are mutagenic
Environmental Health - Effects of HAHs on hepatic gene expression characterized
Environmental Health - Long-term uranium exposure yields dramatic changes in gene expression
Enzymology - Cyclin proteolysis and CDK inhibitors help maintain genomic stability
Enzymology - The enzyme inhibitor DR396 sheds light on DNase gamma activity
Evolutionary Biology - Spot test shows how fruitflies' wing patterns evolve
Familial Hypercholesterolemia - Novel assay detects FH-associated LDLR gene rearrangements
Fibroblasts - Collagens and related proteins identified in human fibroblasts using proteomics
Finance - DNA analysis technology company raises funds
Finance - Dermatology company reports Q4 net income of $6.4M; product revenues up 128%
Finance - Florida-based biotech announces effectiveness of SB-2 registration statement
Finance - Genomics firm reports loss of $0.27 per share
Finance - Pharma company completes $43 million series C financing
Finance - Protein therapeutics company raises EUR 7.0 million
Finance - Provider of medical devices for venous reflux disease reports 4Q 2004 results
Finance - Stem cell-focused biotechnology company announces completion of IPO
Finance - Thalomid maker reports strong revenue growth and profits
Finance - Vaccine maker reports 2004 pro forma earnings down more than 50% from 2003
Gastroenterology - Gene profiles distinguish pancreatic mucinous cystic neoplasms
Gene Expression - Cellular enzyme plays key role in gene regulation
Gene Expression - Glycolysis genes are ubiquitously overexpressed in 24 cancer classes
Gene Expression - Myeloid leukemic cells express genes expressed in normal nonhematopoietic tissue
Gene Expression - Sterol response element binding protein activates spermatogenic cell genes
Gene Expression - expO completes first phase of standardized gene-expression analyses
Gene Profiles - Dense maps of single nucleotide polymorphisms uncover accurate genotypes
Gene Research - Agreement to supply genetic tests for New England Newborn Screening Program set
Gene Research - Broad Institute scientists find genome structure responsible for gene activation
Gene Research - von Willebrand factor studied, multi-effect mutation revealed
Gene Sequencing - How many comparative genomes are enough?
Gene Transcription - What are muscle proteins doing in the nucleus?
Genetic Disorders - Genetic and environmental factors may explain craniofacial in Marfan syndrome
Genetic Disorders - Zebrafish model the origins of aneuploidy
Genomics - Haplotype patterns vary among different populations
Genomics - Racial groupings match genetic profiles, study finds
Genomics - Report describes expression of tilapia extracellular Ca2+-sensing receptor
Genomics - Researchers tout ability of genetic tests to avoid bad drug reactions
Genomics and Genetics - Benefits of miniaturization for DNA microarrays clarified
Genomics and Genetics - Florida to expand genetic disease testing in newborns
Geriatrics - Age-dependent factors stall the efforts of DNA repair enzymes
Glucocorticoids - Glucocorticoids analyzed, reduced TGF-beta bioavailability observed
HIV/AIDS Awarwness - Media company, Kaiser Family Foundation launch year 3 of Know HIV/AIDS campaign
HIV/AIDS Coinfection - HAART immune reconstitution trigger adverse effects in M. leprae coinfection
HIV/AIDS Pathogenesis - CCR5/CCR2 genetic variants not responsible for maintenance of HIV nonprogression
HIV/AIDS Pathogenesis - Changes in HIV-1 V3 region correspond with disease progression
HIV/AIDS Pathogenesis - HIV-1 gp120 reduces brain-derived neurotrophic factor levels
HIV/AIDS Pathogenesis - Improved control of HIV-2 infection may relate to contribution of CD4 response
HIV/AIDS Pathogenesis - Studies add new findings to HIV/AIDS pathogenesis body of knowledge
HIV/AIDS Research - Annexin II may be new target for prevention of HIV-1 infection
HIV/AIDS Research - Peptides specifically binding to HIV-1 psi RNA selected/characterized
HIV/AIDS Research - Pharma company submits three filings of antiretroviral agents to WHO
HIV/AIDS Therapy - Curcumin inhibits acetylation of HIV Tat by p300 as well as virus proliferation
HIV/AIDS Therapy - Highly potent HIV entry inhibitors developed
HIV/AIDS Therapy - P-TEFb kinase inhibitor flavopiridol inhibits HIV transcription elongation
HIV/AIDS Therapy - Reports describe recent advances in HIV/AIDS therapy research
HIV/AIDS Vaccine - Investigational HIV/AIDS vaccine candidate advances to phase II efficacy testing
HIV/AIDS-Related Dementia - Astrocyte specific viral strains identified in HIV dementia
Health Promotion - Jeans too tight? University study shows 50% of adults can blame their genes
Healthcare Coverage - Tenet signs agreement to provide PPO insurance services at 3 Texas hospitals
Hearing Loss - Modifier genes trigger phenotypic expression of a deafness-linked mutation
Heart Disease - Biopharmaceutical company releases results of clinical studies in hypertension
Heart Disease - Published study shows fingertip test identifies coronary disease at early stage
Heart Disease - Treatment of choice for ED in heart disease patients is sildenafil
Hepatitis B - Drug for treatment of chronic hepatitis B up for approval
Hepatitis C - Therapeutics company expands hepatitis C collaboration with Merck
Hepatitis C Therapy - The non-nucleoside inhibitor HCV-371 attacks viral polymerase
Human Papillomavirus - HPV 16 E7 oncogene represses TGF-beta2 promoter by releasing E2F from pRb
Human Papillomavirus - HPV associated with genomic instability
Huntington Disease - Study investigated effects of Huntington disease on autonomic nervous system
Hypertension - Healthcare organization launches program for women and heart disease
Hypertension - Pharma company acquires Cibacen and Cibadrex
Hypertrophic Cardiomyopathy - ECGs should extend into midlife in families with hypertrophic cardiomyopathy
Immunology - Researchers' data advance immunology research
Information Technology - Software company delivers web-based platform for spinal cord injury network
Information Technology - Tools acquired by genomics firm to analyze DNA-related information
Kaposi Sarcoma-Associated Herpesvirus - 6CCC8 mutations severely reduce KSHV LANA1 binding
Kaposi Sarcoma-Associated Herpesvirus - Hematopoietic stem cell mobilization may stimulate KSHV replication
Legionella - Method simultaneously detects genes and epidemiologically types Legionella
Lipids - Hepatic steatosis may be caused by or associated with abnormal lipid metabolism
Lipids - Review compares lipid homeostatis through liver X and thyroid hormone receptors
Lung Cancer - Mutant K-ras(V12) increases COX-2/peroxides/DNA damage in lung cells
Lupus - Gatekeeper gene critical to prevention and cure of lupus
MALT Lymphoma - MALT lymphoma graded by H. pylori eradication/API2-MALT1 fusion detection
Menstruation - Pesticides affect menstrual cycle
Mental Health - 5-HT1A receptor genotypes regulate a patient's response to antidepressants
Mergers & Acquisitions - Medical laboratory acquires pharmaceutical company
Metabolic Disease - Newly uncovered mutations correlate with glycogen storage disease
Microbial Resistance - Carbapenem & ciprofloxacin most effective antimicrobials for ESBL-EK bacteremia
Migraine Headaches - European patent issued for MT 400 technology for treatment of migraine
Multiple Sclerosis - Genetics may explain why women develop MS more often than men
Mutagenesis - Sesquestosome 1 gene mutations play a role in Paget disease of the bone
Mutagenesis - The genotype-phenotype continuum of Wilson disease is extensive
Mycotoxin - Thermal food processing affects structure and toxicity of fumonisin mycotoxins
Myelodysplastic Syndrome - Altered gene expression characterized in MDS hematopoietic progenitors
Myelodysplastic Syndrome - CD34+ resistance to chemotherapy in AML related to antiapoptostic phenotype
Myelodysplastic Syndrome - Material from chromosome 5 translocated to almost all chromosomes in AML
Myocardial Infarction - New research provides insight into gene response following MI
Myocardial Infarction - Pharma company signs new agreement with AstraZeneca
Myopathy - Common genes separate focal myositis cases from systemic disease
Nanotechnology - Institute proves effectiveness of nanotechnology in gene therapy for cancer
Neuritogenesis - Neuritogenesis analyzed, role of ubiquitin ligase regulation of FEZ1 revealed
Neurodegeneration - Chronic complex-induced neurodegeneration studied, distinct mechanisms revealed
Neurofibromatosis - Inflammatory cells highly promising target in NF 1
Neurogenesis - Sensory cranial placode neurogenesis studied, early role of two genes revealed
Neuromuscular Disease - Many patients with amyotrophic lateral sclerosis bear Hfe gene mutations
Neuroscience - Glucocerebrosidase mutations may correlate with the onset of parkinsonism
Neuroscience - Orexin plays key role in food anticipatory activity
Neuroscience - Prion neurotoxicity studied, role of glycosylphosphatidylinositols revealed
Neuroscience - Single-trial tasks significantly modulate hippocampal genes in rats
Neuroscience - The low-density lipoprotein receptor gene has no linkage to migraine headache
Nosocomial Infection - Good infection control practices help prevent nosocomial infections
Nuclear Export - Architecture of CRM1/exportin1 analyzed, role in cooperativity suggested
Nucleic Acid Research - Microfluidic planetary centrifugal mixing enhances microarray hybridization
Nucleoscience - alpha-Synuclein has little influence on proteasome function
Obesity - Researchers call for preventative measures to curb obesity epidemic
Obstetrics - Biomarkers in amniotic fluid diagnose lysosomal storage diseases
Obstructive Sleep Apnea - Obstructive sleep apnea and restless legs triggered by genes
Oncology - Cells normally protected from apoptosis are vulnerable to Fhit gene induction
Oncology - Low NEIL1 activity correlates with gastric cancer pathogenesis
Ophthalmology - Optic chiasm formation analyzed, requirement for Foxd1 demonstrated
Organ Transplantation - Steroid dependency studied in pediatric heart transplant patients
Osteoporosis - Genetics and lifestyle combine to affect susceptibility for osteoporosis
Osteoporosis - Increased risk of osteoporosis associated with gene that one in five people have
Osteporosis - Gene increases risk of osteoporosis in women
Papillomavirus Infection - High incidence of HPV in women with normal cytology
Parkinson Disease - Alpha-synuclein fibrillation analyzed, role of rifampicin revealed
Parkinson Disease - U.K. research could lead to new treatments for Parkinson
Patents - Claims in 5 more patents for in vivo optical imaging of whole animals allowed
Patents - Genzyme files patent infringement suit
Patents - Institute retains rights on a patent based on use of homologous recombination
Patents - MIS technology company announces new patents
Patents - Patent granted for immunology technology in South Africa
Patents - Patents obtained in Japan and the U.S. for refractory leukemia biomarkers
Personnel - David S. Krause, MD, named executive VP, chief medical officer by biopharm firm
Personnel - Dr. Tanvir Khandaker joins board of directors
Personnel - Gene slicing company names member to scientific advisory board
Pharmaceutical Research - Report addresses potential for toxicological assessment technology
Pharmaceuticals - Company links genetic variation to the effect of HRT on C-reactive protein
Pharmacology - Indoprofen stimulates survival motor neuron protein production
Philanthropy - Healthcare company supports diabetes prevention camp for Native American youth
Physiology - Na+/H+ exchange in colonocytes studied, role of zinc receptor revealed
Physiology - Skeletal muscle differentiation studied, basis of inhibition revealed
Pneumocystis Jirovecii - P. jirovecii FAS gene cloned and DHPS drug-resistant mutation evaluated
Pneumonia - Phase 3 clinical studies of antibiotic for hospital acquired pneumonia initiated
Polycystic Ovary Syndrome - Researchers provide details of new studies and findings in the area of polycystic ovary syndrome
Population Study - Biobank deposits amplify the study of dizygotic twinning
Poxvirus - Factors influencing the ability of poxviruses to induce tumors investigated
Product Licensing - Biopharma company gains access to protein expression technology
Product Licensing - Company licenses Conversion Technology, Analysis processes to Mayo Medical
Product Licensing - Glaxo SmithKline licenses PathArt
Product Licensing - Software company licenses MetaCore for RNA interference drug discovery
Professional Education - Pathologists license SNOMED CT mappings for free access through national library
Progenitor Cells - Cortical neurons studied, transcriptional factor expression clarified
Prostate Cancer - CYP3A4*1B/CYP3A43*3 may influence risk of prostate cancer/disease severity
Prostate Cancer - GSTP1 I105V polymorphism not associated with prostate cancer risk
Prostate Cancer - Pivotal phase III ACAPODENE trial begins for the prevention of prostate cancer
Prostate Cancer - Prostate tumors show epigenetic silencing of 14-3-3 sigma
Prostate Cancer - Reports advance knowledge in prostate cancer research
Protein Kinase - Protein kinase Akt/PKB studied, phosphorylation of heme oxygenase-1 shown
Protein Precursors - Cell surface receptor CDO studied, positive regulatory role revealed
Protein Signalling - Differentiation of PC12 cells studied, role of p90(Rsk1) revealed
Protein Signalling - p21(Cip1) degradation analyzed, roles of N-acetylation and ubiquitin clarified
Proteomics - Hsp90 ATPase cycle analyzed, co-chaperone regulation demonstrated
Proteomics - Hypoxia response element antagonist limits VEGF production
Proteomics - Researchers' findings advance proteomics research
Proteomics - Sp3 proteins are negative regulators of beta myosin heavy chain genes
Proteomics - Studies add new findings to proteomics body of knowledge
Proteomics - ZNF322 protein is a member of the zinc-finger transcription factor family
Puberty - Puberty is triggered by a kiss
RNA Research - Actin and nuclear myosin I needed for RNA polymerase I transcription
RNA Research - Progress reported on RSV program and systemic RNAi therapeutics
Receptor Studies - Steroid co-activators back Ets-1-regulated vessel growth
Rheumatoid Arthritis - Japan's regulatory body approves anti-TNF receptor to treat rheumatoid arthritis
Ribosomes - U3 snoRNP studied, basis of assembly and maturation in nucleoplasm clarified
SARS Coronavirus - Findings in SARS coronavirus provide new insights
Sexual & Reproductive Health - Human sexual behaviors exhibit a moderate link to genetic influences
Spinal Cord Injury - Program initiated to develop RNAi therapeutics for spinal cord injury
Staphylococcus Vaccine - Genes required for full virulence of Staphylococcus aureus identified
Stem Cell Research - Marrow transplantation reverses liver damage in animal model
Stem Cell Research - RNA interference inactivates p53 in developing T cells
Stem Cell Research - Study shows timing is everything in coaxing stem cells into becoming other cells
Stem Cell Therapy - Stem cell therapy may be used to treat neurotrauma
Stomach Cancer - COX-2 overexpression may contribute to carcinogenesis
Therapy - RNAi company selected by Genentech to support drug-discovery research
Tissue Engineering - Collagen IX provides a mechanism for cell adhesion to cartilaginous matrix
Tobacco Use - Cigarette smoke activates proinflammatory genes in rodent lungs
Toxicology - Tobacco condensates alter gene expression patterns
Trypanosoma Brucei - Real-time PCR rapid/sensitive for detection of Trypanosoma brucei in blood
Tumor Suppression - Rb tumor suppressor required for stress erythropoiesis
Tumor Suppressor Gene - ING4 is a candidate as a tumor suppressor gene
Type 2 Diabetes - Insulin-focused therapeutics company expands trials of type 2 diabetes treatment
Type 2 Diabetes - Long-term efficacy of insulin 70/30 mix in type 2 diabetes shown in study
Vascular Disease - EGR1 is a target for AhR agonists in lung epithelial cells
Vasculitis - Xenograft model with predominant human PMN infiltration developed
Venezuelan Equine Encephalitis Virus - VEE virus subtype IE genotype continuously circulating in southern Mexico
Virology - Gene therapy corrects Fabry disease in neonatal mice
Virology - Researchers detail new studies and findings in the area of virology
Vitamin E - Vitamin E prevents formation of DNA adducts by lipid peroxidation products
Werner Syndrome - Werner protein analyzed, helicase regulation revealed
West Nile Virus - Genetic alterations in NY99 WNV genotype responsible for crow-virulent phenotype
West Nile Virus - West Nile virus infection of embryo fibroblasts associated with TNF production
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