Stomach Cancer
COX-2 overexpression may contribute to carcinogenesis
Published in Genomics and Genetics Weekly, February 25th, 2005
According to recent research published in the journal Molecular Pharmacology, "Gastric epithelial cells were incubated with a panel of clinical isolates of Helicobacter pylori, including nonulcer dyspepsia with gastritis (HS, n=20), gastric ulcer (HU, n=20), duodenal ulcer (HD, n=21), and gastric cancer (HC, n=20).
"HC strains induced a higher cyclooxygenase-2 (COX-2) expression than those from HS, HD, and HU. The bacterial virulence factors and the host cellular pathways were investigated."
"Virulence genes of iceA,...
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